Global Patent Index - EP 1140073 A1

EP 1140073 A1 20011010 - COMBINATIONS OF FARNESYL TRANSFERASE INHIBITORS AND IRINOTECAN OR CAMPTOTHECIN FOR TREATING CANCER

Title (en)

COMBINATIONS OF FARNESYL TRANSFERASE INHIBITORS AND IRINOTECAN OR CAMPTOTHECIN FOR TREATING CANCER

Title (de)

KOMBINATIONEN DER FARNESYLTRANSFERASEHEMMER UND DER IRINOTHECAN ODER CAMPTOTHECIN FÜR KREBSTHERAPIE

Title (fr)

COMBINAISONS DES INHIBITEURS DE FARNESYLE TRANSFERASE ET IRINOTECAN OU CAMPTOTHECINE POR LE TRAITEMENT DE CANCERS

Publication

EP 1140073 A1 20011010 (FR)

Application

EP 99961114 A 19991220

Priority

  • FR 9903207 W 19991220
  • FR 9816125 A 19981221

Abstract (en)

[origin: FR2787327A1] Compositions containing a farnesyl transferase inhibitor (I) and a topoisomerase inhibitor (II). Compositions containing a farnesyl transferase inhibitor of formula (I) in racemic or optical isomeric form, and its salts and a topoisomerase inhibitor (II). Ar = 2,3-dihydro-1,4-benzodioxin-6-yl , 2,3-dihydrobenzofuran-5-yl or substituted phenyl; R = COOH, -COOMe or -CONH(R8); R1, R2 = H or methoxy; provided that R1 and R2 are different; R3, R4 = H and one may also be methoxy; R5 = H or methyl; R8 = methyl substituted by 3-pyridyl; X = methylene or vinyldiyl.

IPC 1-7

A61K 31/415; A61K 31/47

IPC 8 full level

A61K 45/00 (2006.01); A61K 31/4035 (2006.01); A61K 31/4439 (2006.01); A61K 31/4545 (2006.01); A61K 31/47 (2006.01); A61P 17/06 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 43/00 (2006.01)

CPC (source: EP US)

A61K 31/4035 (2013.01 - EP US); A61K 31/4439 (2013.01 - EP US); A61K 31/47 (2013.01 - EP US); A61P 17/06 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP)

C-Set (source: EP US)

A61K 31/47 + A61K 2300/00

Citation (search report)

See references of WO 0037076A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

FR 2787327 A1 20000623; FR 2787327 B1 20030117; AU 1783800 A 20000712; EP 1140073 A1 20011010; JP 2002532550 A 20021002; US 6342487 B1 20020129; WO 0037076 A1 20000629

DOCDB simple family (application)

FR 9816125 A 19981221; AU 1783800 A 19991220; EP 99961114 A 19991220; FR 9903207 W 19991220; JP 2000589187 A 19991220; US 34629699 A 19990702