EP 1140138 A2 20011010 - THERAPEUTIC APPLICATIONS OF FLINT POLYPEPTIDES
Title (en)
THERAPEUTIC APPLICATIONS OF FLINT POLYPEPTIDES
Title (de)
THERAPEUTISCHE VERWENDUNGEN VON FLINT POLYPEPTIDEN
Title (fr)
APPLICATIONS THERAPEUTIQUES DE POLYPEPTIDES FLINT
Publication
Application
Priority
- US 9930734 W 19991221
- US 11340798 P 19981222
- US 9906797 W 19990330
- US 17223999 P 19991020
Abstract (en)
[origin: WO0037094A2] Mature FLINT protein (mFLINT) binds FasL and LIGHT, and prevents FasL-Fas interaction. mFLINT inhibits FasL-Fas-mediated apoptotic and proinflammatory activity, and is useful in treating disorders that may be associated with abnormal apoptosis and inflammation. The invention provides the amino acid and nucleotide sequences of FLINT and mature FLINT. Therapeutic compositions and methods of treatment utilizing mFLINT also are provided.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61P 1/04 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 19/10 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); C07K 14/705 (2006.01); A61K 35/00 (2006.01)
CPC (source: EP)
A61P 1/04 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 19/10 (2017.12); A61P 35/00 (2017.12); A61P 37/02 (2017.12); C07K 14/70578 (2013.01); A61K 35/00 (2013.01)
Citation (search report)
See references of WO 0037094A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0037094 A2 20000629; WO 0037094 A3 20001109; AU 2211100 A 20000712; CA 2358508 A1 20000629; EP 1140138 A2 20011010; JP 2003520761 A 20030708
DOCDB simple family (application)
US 9930734 W 19991221; AU 2211100 A 19991221; CA 2358508 A 19991221; EP 99966602 A 19991221; JP 2000589204 A 19991221