EP 1140143 A2 20011010 - RIBAVIRIN-PEGYLATED INTERFERON ALFA INDUCTION HCV COMBINATION THERAPY
Title (en)
RIBAVIRIN-PEGYLATED INTERFERON ALFA INDUCTION HCV COMBINATION THERAPY
Title (de)
RIBAVIRIN-PEG-INTERFERON ALPHA INDUKTIONS HCV KOMBINATIONSTHERAPIE
Title (fr)
TRAITEMENT DU VHC PAR INDUCTION D'INTERFERON-ALPHA PEGYLE COMBINE LA RIBAVIRINE
Publication
Application
Priority
- US 9927935 W 19991216
- US 21587698 A 19981218
Abstract (en)
[origin: WO0037110A2] The use of ribavirin and interferon alpha for the manufacture of pharmaceutical compositions for treating a patient having chronic hepatitis C infection, e.g., a patient having HCV genotype 1, 2 or 3, to eradicate detectable HCV-RNA by a method comprising administering an effective amount of ribavirin in association with an effective amount of pegylated interferon alpha, characterised in that treating patients having chronic hepatitis C infections is effected in two treatment time periods: (a) a first treatment time period of at least 20 to 30 wherein a therapeutically effective amount of ribavirin and a therapeutically effective induction dosing amount of pegylated interferon-alfa, e.g., pegylated interferon-alfa-2b sufficient to at least substantially lower, and preferably to eradicate, detectable HCV-RNA, are administered; and (b) a second treatment time period of at least 20 to 30 weeks wherein a therapeutically effective amount of ribavirin and a therapeutically effective amount of pegylated interferon-alfa are administered sufficient to maintian no detectable HCV-RNA for at least 20-30 weeks are administered after the end of the first treatment time period and to maintain no detectable HCV-RNA for at least 24 weeks after the end of the second treatment time period is disclosed.
IPC 1-7
IPC 8 full level
A61K 31/7052 (2006.01); A61K 38/21 (2006.01); A61P 31/14 (2006.01)
CPC (source: EP)
A61K 38/212 (2013.01); A61P 31/14 (2017.12)
C-Set (source: EP)
Citation (search report)
See references of WO 0037110A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0037110 A2 20000629; WO 0037110 A3 20000914; AR 021876 A1 20020807; AU 2157000 A 20000712; CA 2354536 A1 20000629; EP 1140143 A2 20011010; JP 2003507322 A 20030225; PE 20001369 A1 20001209
DOCDB simple family (application)
US 9927935 W 19991216; AR P990106462 A 19991216; AU 2157000 A 19991216; CA 2354536 A 19991216; EP 99965894 A 19991216; JP 2000589220 A 19991216; PE 00129299 A 19991217