EP 1140171 A1 20011010 - METHODS AND PRODUCTS FOR REGULATING LECTIN COMPLEMENT PATHWAY ASSOCIATED COMPLEMENT ACTIVATION
Title (en)
METHODS AND PRODUCTS FOR REGULATING LECTIN COMPLEMENT PATHWAY ASSOCIATED COMPLEMENT ACTIVATION
Title (de)
METHODEN UND PRODUKTE ZUR REGULATION DER, MIT DEM LECTIN-KOMPLEMENTSYSTEM ASSOZIIERTEN, KOMPLEMENTAKTIVIERUNG
Title (fr)
TECHNIQUES ET PRODUITS PERMETTANT DE REGULER L'ACTIVATION DU COMPLEMENT ASSOCIEE A LA VOIE DU COMPLEMENT A LECTINE
Publication
Application
Priority
- US 9929919 W 19991215
- US 11239098 P 19981215
Abstract (en)
[origin: WO0035483A1] The invention relates to methods and products for regulating lectin complement pathway associated complement activation. The methods include both in vitro and in vivo methods for inhibiting lectin complement pathway associated complement activation. The methods are accomplished by contacting a mammalian cell having surface exposed MBL ligand with an effective amount of a mannan binding lectin inhibitor to inhibit lectin complement pathway associated complement activation. The mannan binding lectin inhibitor may be administered to a subject to prevent cellular injury mediated by lectin complement pathway associated complement activation. The products of the invention include compositions of a mannan binding lectin inhibitor. The mannan binding lectin inhibitor is an isolated mannan binding lectin binding peptide that selectively binds to a human mannan binding lectin epitope and that inhibits lectin complement pathway associated complement activation. The products also include hybridoma cell lines and pharmaceutical compositions.
IPC 1-7
IPC 8 full level
C12N 15/02 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61P 7/08 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 19/02 (2006.01); A61P 43/00 (2006.01); C07K 14/705 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61P 7/08 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 19/02 (2017.12); A61P 43/00 (2017.12); C07K 16/18 (2013.01); A61K 2039/505 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0035483 A1 20000622; CA 2347734 A1 20000622; EP 1140171 A1 20011010; EP 1140171 A4 20020313; JP 2002532079 A 20021002
DOCDB simple family (application)
US 9929919 W 19991215; CA 2347734 A 19991215; EP 99967362 A 19991215; JP 2000587802 A 19991215