Global Patent Index - EP 1140171 A4

EP 1140171 A4 20020313 - METHODS AND PRODUCTS FOR REGULATING LECTIN COMPLEMENT PATHWAY ASSOCIATED COMPLEMENT ACTIVATION

Title (en)

METHODS AND PRODUCTS FOR REGULATING LECTIN COMPLEMENT PATHWAY ASSOCIATED COMPLEMENT ACTIVATION

Title (de)

METHODEN UND PRODUKTE ZUR REGULATION DER, MIT DEM LECTIN-KOMPLEMENTSYSTEM ASSOZIIERTEN, KOMPLEMENTAKTIVIERUNG

Title (fr)

TECHNIQUES ET PRODUITS PERMETTANT DE REGULER L'ACTIVATION DU COMPLEMENT ASSOCIEE A LA VOIE DU COMPLEMENT A LECTINE

Publication

EP 1140171 A4 20020313 (EN)

Application

EP 99967362 A 19991215

Priority

  • US 9929919 W 19991215
  • US 11239098 P 19981215

Abstract (en)

[origin: WO0035483A1] The invention relates to methods and products for regulating lectin complement pathway associated complement activation. The methods include both in vitro and in vivo methods for inhibiting lectin complement pathway associated complement activation. The methods are accomplished by contacting a mammalian cell having surface exposed MBL ligand with an effective amount of a mannan binding lectin inhibitor to inhibit lectin complement pathway associated complement activation. The mannan binding lectin inhibitor may be administered to a subject to prevent cellular injury mediated by lectin complement pathway associated complement activation. The products of the invention include compositions of a mannan binding lectin inhibitor. The mannan binding lectin inhibitor is an isolated mannan binding lectin binding peptide that selectively binds to a human mannan binding lectin epitope and that inhibits lectin complement pathway associated complement activation. The products also include hybridoma cell lines and pharmaceutical compositions.

IPC 1-7

A61K 39/395; C12N 5/06; C12N 5/16; G01N 33/50

IPC 8 full level

C12N 15/02 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61P 7/08 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 19/02 (2006.01); A61P 43/00 (2006.01); C07K 14/705 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP)

A61P 7/08 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 19/02 (2017.12); A61P 43/00 (2017.12); C07K 16/18 (2013.01); A61K 2039/505 (2013.01)

Citation (search report)

  • [X] WO 9106010 A1 19910502 - INST OF CHILD HEALTH [GB]
  • [X] WO 8901519 A1 19890223 - CHILDRENS HOSPITAL CORP [US]
  • [X] PATENT ABSTRACTS OF JAPAN vol. 018, no. 410 (C - 1232) 2 August 1994 (1994-08-02)
  • [X] CHAKA W ET AL: "Induction of TNF-alpha in human peripheral blood mononuclear cells by the mannoprotein of cryptococcus neoformans involves human mannose binding protein", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 159, 1997, pages 2979 - 2985, XP002145899, ISSN: 0022-1767
  • [X] COLLARD C D ET AL: "REOXYGENATION OF HYPOXIC HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVECS) ACTIVATES THE LECTIN COMPLEMENT PATHWAY (LCP)", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 12, no. 4, 17 March 1998 (1998-03-17), pages A29, XP000944437, ISSN: 0892-6638
  • [X] ENDO M ET AL: "GLOMERULA DEPOSITION OF MANNOSE-BINDING LECTIN (MBL) INDICATES A NOVEL MECHANISM OF COMPLEMENT ACTIVATION IN IGA NEPHROPATHY", NEPHROLOGY DIALYSIS TRANSPLANTATION, OXFORD UNIVERSITY PRESS, GB, vol. 13, no. 8, 1998, pages 1984 - 1990, XP000874166, ISSN: 0931-0509
  • [PX] COLLARD C D ET AL: "ENDOTHELIAL REOXYGENATION ACTIVATES THE LECTIN COMPLEMENT PATHWAY: INHIBITION WITH ANTI-HUMAN MANNOSE BINDING LECTIN(MBL) THERAPY", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 36, no. 4/5, March 1999 (1999-03-01), pages 278, XP000944464, ISSN: 0026-895X
  • [PX] LHOTTA K ET AL: "GLOMERULAR DEPOSITION OF MANNOSE-BINDING LECTIN IN HUMAN GLOMERULONEPHRITIS", NEPHROLOGY DIALYSIS TRANSPLANTATION, OXFORD UNIVERSITY PRESS, GB, vol. 14, no. 4, April 1999 (1999-04-01), pages 881 - 886, XP000944395, ISSN: 0931-0509
  • [A] PATENT ABSTRACTS OF JAPAN vol. 1996, no. 01 31 January 1996 (1996-01-31)
  • [A] TENNER A J ET AL: "MANNOSE BINDING PROTEIN (MBP) ENHANCES MONONUCLEAR PHAGOCYTE FUNCTION VIA A RECEPTOR THAT CONTAINS THE 126,00 MR COMPONENT OF THE C1Q RECEPTOR", IMMUNITY, CELL PRESS, US, vol. 3, no. 4, 1 October 1995 (1995-10-01), pages 485 - 493, XP002058774, ISSN: 1074-7613
  • [A] TERAI I ET AL: "ALPHA2-MACROGLOBULIN BINDS TO AND INHIBITS MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASE", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 7, no. 10, October 1995 (1995-10-01), pages 1579 - 1584, XP001034131, ISSN: 0953-8178
  • See references of WO 0035483A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0035483 A1 20000622; CA 2347734 A1 20000622; EP 1140171 A1 20011010; EP 1140171 A4 20020313; JP 2002532079 A 20021002

DOCDB simple family (application)

US 9929919 W 19991215; CA 2347734 A 19991215; EP 99967362 A 19991215; JP 2000587802 A 19991215