EP 1140745 A1 20011010 - COLCHINOL DERIVATIVES AS VASCULAR DAMAGING AGENTS
Title (en)
COLCHINOL DERIVATIVES AS VASCULAR DAMAGING AGENTS
Title (de)
COLCHINOLDERIVATE ALS GEFÄSSSCHÄDIGENDE MITTEL
Title (fr)
DERIVES DE COLCHINOL UTILISES COMME AGENTS DE DEGRADATION VASCULAIRE
Publication
Application
Priority
- GB 9904436 W 19991224
- GB 9900334 A 19990107
Abstract (en)
[origin: US2006128633A1] The invention relates to the use of compounds of formula (I): wherein X is -C(O)-, -C(S)-, -C-NOH, or -CH(R<SUP>7</SUP>)- wherein R<SUP>7 </SUP>is hydrogen, hydroxy, C<SUB>1-7</SUB>alkoxy, -OR<SUP>8 </SUP>or -NR<SUP>8</SUP>R<SUP>9 </SUP>(wherein R<SUP>8 </SUP>is a group -Y<SUP>1</SUP>R<SUP>10 </SUP>(wherein Y<SUP>1 </SUP>is a direct bond, -C(O)-, -C(S)-, -S-, -C(O)O-, -C(O)NR<SUP>11</SUP>-, -SO<SUB>2</SUB>- or -SO<SUB>2</SUB>NR<SUP>12</SUP>- (wherein R<SUP>11 </SUP>and R<SUP>12</SUP>, which may be the same or different, each independently represents hydrogen; C<SUB>1-3</SUB>alkyl or C<SUB>1-3</SUB>alkoxyC<SUB>2-3</SUB>alkyl) and R<SUP>10 </SUP>is as defined herein, R<SUP>9 </SUP>includes hydrogen; R<SUP>11</SUP>, R<SUP>12 </SUP>and R<SUP>13 </SUP>are as defined herein and are preferably methyl; R<SUP>4</SUP>, R<SUP>5 </SUP>and R<SUP>6 </SUP>are as defined herein with the proviso that R<SUP>5 </SUP>is not hydroxy, alkoxy, substituted alkoxy, -OPO<SUB>3</SUB>H<SUB>2</SUB>, -O-C<SUB>1-7</SUB>alkanoyl or benzyloxy; and salts thereof in the manufacture of a medicament for use in the production of a vascular damaging effect in warm-blooded animals such as humans. The present invention further relates to compounds of the formula (I), pharmaceutical compositions containing them, processes for their preparation and to a method of treatment using the compounds to produce a vascular damaging effect in a warm-blooded animal such as a human. The compounds of formula (I) and the pharmaceutically acceptable salts thereof may be useful in the treatment of a number of disease states including cancer and rheumatoid arthritis.
IPC 1-7
IPC 8 full level
C07D 295/08 (2006.01); A61K 31/165 (2006.01); A61K 31/167 (2006.01); A61K 31/192 (2006.01); A61K 31/197 (2006.01); A61K 31/198 (2006.01); A61K 31/225 (2006.01); A61K 31/255 (2006.01); A61K 31/265 (2006.01); A61K 31/27 (2006.01); A61K 31/4545 (2006.01); A61K 31/495 (2006.01); A61K 31/5375 (2006.01); A61K 31/661 (2006.01); A61K 31/704 (2006.01); A61P 9/00 (2006.01); A61P 35/00 (2006.01); C07B 53/00 (2006.01); C07C 68/02 (2006.01); C07C 69/96 (2006.01); C07C 213/00 (2006.01); C07C 217/74 (2006.01); C07C 231/02 (2006.01); C07C 231/12 (2006.01); C07C 233/23 (2006.01); C07C 233/43 (2006.01); C07C 237/04 (2006.01); C07C 237/48 (2006.01); C07C 249/12 (2006.01); C07C 251/44 (2006.01); C07C 253/20 (2006.01); C07C 255/60 (2006.01); C07C 257/14 (2006.01); C07C 269/04 (2006.01); C07C 269/06 (2006.01); C07C 271/22 (2006.01); C07C 271/24 (2006.01); C07C 271/52 (2006.01); C07C 273/18 (2006.01); C07C 275/42 (2006.01); C07C 301/02 (2006.01); C07C 303/28 (2006.01); C07C 303/40 (2006.01); C07C 305/24 (2006.01); C07C 307/08 (2006.01); C07C 309/15 (2006.01); C07F 9/09 (2006.01); C07F 9/40 (2006.01); C07H 15/248 (2006.01)
CPC (source: EP KR US)
A61K 31/16 (2013.01 - KR); A61K 31/165 (2013.01 - EP US); A61K 31/6615 (2013.01 - KR); A61P 9/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0040529 A1 20000713; AT E252529 T1 20031115; AU 1882300 A 20000724; AU 760830 B2 20030522; BR 9916790 A 20011204; CA 2355302 A1 20000713; CN 1398247 A 20030219; DE 69912313 D1 20031127; DE 69912313 T2 20040826; DK 1140745 T3 20040223; EP 1140745 A1 20011010; EP 1140745 B1 20031022; ES 2211206 T3 20040701; GB 9900334 D0 19990224; GB 9930610 D0 20000216; HK 1040703 A1 20020621; IL 143978 A0 20020421; JP 2002534400 A 20021015; KR 20010101402 A 20011114; MX PA01006474 A 20030606; MY 130755 A 20070731; NO 20013367 D0 20010706; NO 20013367 L 20010905; NZ 512398 A 20031128; PT 1140745 E 20040331; US 2006128633 A1 20060615; US 7135502 B1 20061114; ZA 200105065 B 20020920
DOCDB simple family (application)
GB 9904436 W 19991224; AT 99962468 T 19991224; AU 1882300 A 19991224; BR 9916790 A 19991224; CA 2355302 A 19991224; CN 99815443 A 19991224; DE 69912313 T 19991224; DK 99962468 T 19991224; EP 99962468 A 19991224; ES 99962468 T 19991224; GB 9900334 A 19990107; GB 9930610 A 19991224; HK 02102295 A 20020326; IL 14397899 A 19991224; JP 2000592241 A 19991224; KR 20017008586 A 20010706; MX PA01006474 A 19991224; MY PI20000041 A 20000105; NO 20013367 A 20010706; NZ 51239899 A 19991224; PT 99962468 T 19991224; US 25601805 A 20051024; US 86992501 A 20010814; ZA 200105065 A 20010620