EP 1140867 A1 20011010 - NEW BETA-AMIDE AND BETA-SULFONAMIDE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS
Title (en)
NEW BETA-AMIDE AND BETA-SULFONAMIDE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS
Title (de)
NEUE BETA-AMIDO- UND BETA-SULFONAMIDOCARBONSÄUREDERIVATE, IHRE HERSTELLUNG UND VERWENDUNG ALS ENDOTHELIN-REZEPTORANTAGONISTEN
Title (fr)
NOUVEAUX DERIVES D'ACIDES BETA-AMIDO- ET BETA-SULFONAMIDOCARBOXYLIQUES, LEUR PRODUCTION ET LEUR UTILISATION COMME ANTAGONISTES DES RECEPTEURS D'ENDOTHELINE
Publication
Application
Priority
- DE 19858779 A 19981218
- EP 9909679 W 19991209
Abstract (en)
[origin: WO0037450A1] The invention relates to carboxylic acid derivatives of formula (I), in which the substituents have the following meanings: R<1> is tetrazol or a group (a); W and Z, can be identical or different and are nitrogen or methine, provided that if W and Z are methine, then Q is nitrogen; X is nitrogen or CR<9>; Y is nitrogen or CR<10>; Q is nitrogen or CR<11>, provided that if Q is nitrogen then X is CR<5> and Y is CR<10>; R<2> and R<3> are identical or different and are possibly substituted phenyl or naphthyl or phenyl or naphthyl which are linked in an ortho position via a direct bond, a methlyene, ethylene or ethenylene group, an oxygen or sulfur atom or a SO2-, NH- or N-alkyl group or possibly substituted C5-C6-cycloalkyl; R<4> is a rest (b) or (c); and R<5> is hydrogen, C1-C4-alkyl. The invention further relates to their preparation and their use as endothelin receptor antagonists. The invention also relates to compounds of formula (II) and a structural fragment of formula (d) in which the rests R<1>, R<2>, R<3>, R<4> and R<5> have the meanings given in claim no. 1 and to their use as structural elements in an endothelin receptor antagonist.
IPC 1-7
C07D 251/22; A61K 31/53; C07D 239/34; A61K 31/505; C07D 239/60; C07D 401/12; C07C 235/52
IPC 8 full level
A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/53 (2006.01); A61P 9/04 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 13/08 (2006.01); C07D 251/24 (2006.01); A61P 13/12 (2006.01); A61P 15/10 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07C 229/34 (2006.01); C07C 233/87 (2006.01); C07C 235/52 (2006.01); C07D 239/34 (2006.01); C07D 251/22 (2006.01); C07D 401/12 (2006.01); C07D 491/048 (2006.01)
CPC (source: EP KR)
A61K 31/506 (2013.01 - KR); A61P 9/00 (2018.01 - EP); A61P 9/04 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 9/12 (2018.01 - EP); A61P 13/00 (2018.01 - EP); A61P 13/08 (2018.01 - EP); A61P 13/12 (2018.01 - EP); A61P 15/10 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07C 229/34 (2013.01 - EP KR); C07C 235/52 (2013.01 - EP KR); C07D 239/34 (2013.01 - EP KR); C07D 251/22 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0037450 A1 20000629; AR 023353 A1 20020904; AU 3036400 A 20000712; BG 105618 A 20020131; BR 9916331 A 20010911; CA 2355251 A1 20000629; CN 1334806 A 20020206; CZ 20012186 A3 20020717; DE 19858779 A1 20000621; EP 1140867 A1 20011010; HK 1042095 A1 20020802; HU P0201321 A2 20021228; HU P0201321 A3 20030228; IL 143451 A0 20020421; JP 2002533330 A 20021008; KR 20010101279 A 20011114; NO 20013000 D0 20010615; NO 20013000 L 20010815; SK 8682001 A3 20020806; TR 200101780 T2 20011121
DOCDB simple family (application)
EP 9909679 W 19991209; AR P990106523 A 19991217; AU 3036400 A 19991209; BG 10561801 A 20010618; BR 9916331 A 19991209; CA 2355251 A 19991209; CN 99814580 A 19991209; CZ 20012186 A 19991209; DE 19858779 A 19981218; EP 99964533 A 19991209; HK 02104116 A 20020531; HU P0201321 A 19991209; IL 14345199 A 19991209; JP 2000589522 A 19991209; KR 20017007615 A 20010616; NO 20013000 A 20010615; SK 8682001 A 19991209; TR 200101780 T 19991209