EP 1140912 A1 20011010 - PROCESS FOR THE PREPARATION OF AN ACETATE SALT OF PAROXETINE OR PAROXETINE ANALOGUES
Title (en)
PROCESS FOR THE PREPARATION OF AN ACETATE SALT OF PAROXETINE OR PAROXETINE ANALOGUES
Title (de)
VERFAHREN ZUR HERSTELLUNG EINES ACETAT-SALZES VON PAROXETINE ODER PAROXETIN-ANALOGEN
Title (fr)
PROCEDE DE PREPARATION D'UN SEL D'ACETATE DE PAROXETINE OU D'ANALOGUES DE PAROXETINE
Publication
Application
Priority
- GB 9904370 W 19991222
- GB 9828781 A 19981229
Abstract (en)
[origin: WO0039123A1] The present invention relates to a new process for the preparation of an acetate salt of a compound of formula (1) in which R<1> is a substituted phenyl group, preferably 3,4-methylenedioxyphenyl; the process comprising contacting a solution of the compound of formula (1) with an amine acetic acid salt. The (-) trans isomer of 4-(4'-fluorophenyl)-3-(3',4'methylenedioxyphenoxymethyl)-piperidine (paroxetine) is an important compound having antidepressant and anti-Parkinson properties. This compound is used in therapy as the hydrochloride salt to treat inter alia depression, obsessive compulsive disorder (OCD) and panic.
IPC 1-7
IPC 8 full level
A61K 31/451 (2006.01); A61P 1/14 (2006.01); A61P 3/04 (2006.01); A61P 15/00 (2006.01); A61P 17/14 (2006.01); A61P 25/04 (2006.01); A61P 25/06 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); A61P 25/32 (2006.01); C07D 211/22 (2006.01)
CPC (source: EP)
A61P 1/14 (2017.12); A61P 3/04 (2017.12); A61P 15/00 (2017.12); A61P 17/14 (2017.12); A61P 25/04 (2017.12); A61P 25/06 (2017.12); A61P 25/22 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 25/30 (2017.12); A61P 25/32 (2017.12); C07D 211/22 (2013.01)
Citation (search report)
See references of WO 0039123A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0039123 A1 20000706; AU 1877300 A 20000731; EP 1140912 A1 20011010; GB 9828781 D0 19990217; JP 2002533459 A 20021008
DOCDB simple family (application)
GB 9904370 W 19991222; AU 1877300 A 19991222; EP 99962415 A 19991222; GB 9828781 A 19981229; JP 2000591034 A 19991222