EP 1140913 A1 20011010 - THIOUREA INHIBITORS OF HERPES VIRUSES
Title (en)
THIOUREA INHIBITORS OF HERPES VIRUSES
Title (de)
THIOUREA INHIBITOREN VON HERPESVIREN
Title (fr)
INHIBITEURS DE THIO-UREE DES VIRUS DE L'HERPES
Publication
Application
Priority
- US 9928892 W 19991206
- US 20854098 A 19981209
Abstract (en)
[origin: CA2351390A1] Compounds of formula (1) wherein, R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, -CN, -NO2, -CO2R6,-COR6, -OR6, -SR6, - SOR6, -SO2R6, -CONR7R8, -NR6N(R7R8), -N(R7R8) or W-Y-(CH2)n-Z; or R2 and R3 or R3 and R4, taken together from a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalky l of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; A is heteroaryl; W is O, NR6, or is absent; Y is -(CO)- or - (CO2)-, or is absent; Z is alkyl of 1 to 4 carbon atoms, -CN, -CO2R6, COR6, - CONR7R8, -OCOR6, -NR6COR7, -OCONR6, -OR6, -SR6, -SOR6, -SO2R6, SR6N(R7R8), - N(R7R8) or phenyl; G is aryl or heteroaryl; X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylaminoof 1 to 6 carbon atoms, or (CH)J ; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpes viruses -6 and -7, and Kaposi herpesvirus.
IPC 1-7
C07D 405/12; C07D 417/12; C07D 213/81; C07D 213/75; A61K 31/33; A61P 31/12
IPC 8 full level
A61K 31/12 (2006.01); A61K 31/33 (2006.01); A61K 31/425 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); C07D 213/81 (2006.01); A61K 31/443 (2006.01); A61K 31/4436 (2006.01); A61K 31/444 (2006.01); A61P 31/12 (2006.01); A61P 31/22 (2006.01); C07D 213/75 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 417/12 (2006.01)
IPC 8 main group level
CPC (source: EP KR)
C07C 335/20 (2013.01 - KR); C07C 335/22 (2013.01 - KR); C07D 213/75 (2013.01 - EP); C07D 213/81 (2013.01 - EP); C07D 217/26 (2013.01 - KR); C07D 307/81 (2013.01 - KR); C07D 307/85 (2013.01 - KR); C07D 405/12 (2013.01 - EP); C07D 417/12 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
AU 3112200 A 20000626; AU 756043 B2 20030102; BG 105580 A 20020131; BR 9916042 A 20011204; CA 2351390 A1 20000615; CN 1335843 A 20020213; CZ 20011958 A3 20011017; EA 200100637 A1 20011224; EP 1140913 A1 20011010; HU P0104758 A2 20020429; HU P0104758 A3 20020528; ID 29064 A 20010726; IL 143203 A0 20020421; JP 2002531558 A 20020924; KR 20010086082 A 20010907; NO 20012836 D0 20010608; NO 20012836 L 20010808; PL 348177 A1 20020506; SK 7692001 A3 20020910; TR 200101598 T2 20011022; ZA 200104373 B 20020918
DOCDB simple family (application)
AU 3112200 A 19991206; BG 10558001 A 20010608; BR 9916042 A 19991206; CA 2351390 A 19991206; CN 99815807 A 19991206; CZ 20011958 A 19991206; EA 200100637 A 19991206; EP 99965143 A 19991206; HU P0104758 A 19991206; ID 20011230 A 19991206; IL 14320399 A 19991206; JP 2000586716 A 19991206; KR 20017007051 A 20010605; NO 20012836 A 20010608; PL 34817799 A 19991206; SK 7692001 A 19991206; TR 200101598 T 19991206; ZA 200104373 A 20010528