Title (en)

EXPRESSION VECTORS COMPRISING MULTIPLE SHEAR STRESS RESPONSIVE ELEMENTS (SSRE) AND A GENE OF INTEREST AND METHODS OF USE THEREOF

Title (de)

EXPRESSIONSVEKTOREN, WELCHE MULTIPLE, AUF SCHERBELASTUNG REAGIERENDE ELEMENTE (SSRE) UMFASSEN UND EIN GEN UND VERFAHREN IHRER ANWENDUNG

Title (fr)

VECTEURS D'EXPRESSION COMPRENANT DES ELEMENTS MULTIPLES SENSIBLES A DES CONTRAINTES DE CISAILLEMENT (SSRE), GENE ET LEURS PROCEDES D'UTILISATION

Publication

EP 1141266 A4 20020925 (EN)

Application

EP 99961261 A 19991223

Priority

• IL 9900702 W 19991223
• US 11386398 P 19981224
• US 22051098 A 19981224

Abstract (en)

[origin: WO0039275A2] This invention provides expression vectors comprising multiple shear stress responsive elements and one or more genes of interest and methods of treating disorders related to or associated with vasculogenesis and/or angiogenesis conditions.

IPC 1-7

C12N 15/00; C12N 5/00; C12N 15/63; A61K 48/00; A01N 63/00; C07H 21/04; C12N 15/85

IPC 8 full level

A61K 31/713 (2006.01); A61K 35/76 (2006.01); A61K 48/00 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); A61P 7/02 (2006.01); A61P 9/02 (2006.01); A61P 9/04 (2006.01); A61P 9/06 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 11/00 (2006.01); A61P 13/10 (2006.01); A61P 17/02 (2006.01); A61P 19/02 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)

CPC (source: EP)

A61P 3/06 (2017.12); A61P 3/10 (2017.12); A61P 7/02 (2017.12); A61P 9/02 (2017.12); A61P 9/04 (2017.12); A61P 9/06 (2017.12); A61P 9/08 (2017.12); A61P 9/10 (2017.12); A61P 9/12 (2017.12); A61P 11/00 (2017.12); A61P 13/10 (2017.12); A61P 17/02 (2017.12); A61P 19/02 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C12N 15/85 (2013.01); A61K 48/00 (2013.01); C12N 2830/002 (2013.01); C12N 2830/15 (2013.01)

Citation (search report)

• [A] WO 9845468 A1 19981015 - NASA [US], et al
• [X] RESNICK N ET AL: "HEMODYNAMIC FORCES ARE COMPLEX REGULATORS OF ENDOTHELIAL GENE EXPRESSION", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 10, no. 9, 1 July 1995 (1995-07-01), pages 874 - 882, XP002075318, ISSN: 0892-6638
• [X] KHACHIGIAN LEVON M ET AL: "Egr-1 is activated in endothelial cells exposed to fluid shear stress and interacts with a novel shear-stress-response element in the PDGF A-chain promoter.", ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol. 17, no. 10, 1997, pages 2280 - 2286, XP002207169, ISSN: 1079-5642
• [Y] HAMMOND T G ET AL: "EPITHELIAL CELL GENE EXPRESSION IS SHEAR STRESS RESPONSIVE", MOLECULAR BIOLOGY OF THE CELL, BETHESDA, MD, US, vol. SUPPL, no. 8, 13 December 1997 (1997-12-13), pages 433a, XP002075321, ISSN: 1059-1524
• [Y] SUMPIO BAUER E ET AL: "Regulation of tPA in endothelial cells exposed to cyclic strain: Role of CRE, AP-2, and SSRE binding sites.", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 273, no. 5 PART 1, November 1997 (1997-11-01), pages C1441 - C1448, XP002207170, ISSN: 0002-9513 & BAUER E. SUMPIO ET AL.: "Regulation of PDGF-B in Endothelial Cells exposed to cyclic strain", ARTERIOSCLER. THROMB. VASC. BIOL., vol. 18, no. 3, March 1998 (1998-03-01), pages 349 - 355, XP002207171
• [A] MIYAHARA K ET AL: "CLONING AND STRUCTURAL CHARACTERIZATION OF THE HUMAN ENDOTHELIAL NITRIC-OXIDE-SYNTHASE GENE", EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 223, no. 3, 1 August 1994 (1994-08-01), pages 719 - 726, XP000610193, ISSN: 0014-2956
• See references of WO 0039275A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0039275 A2 20000706; WO 0039275 A3 20001026; AU 1795400 A 20000731; EP 1141266 A2 20011010; EP 1141266 A4 20020925; JP 2002533113 A 20021008

DOCDB simple family (application)

IL 9900702 W 19991223; AU 1795400 A 19991223; EP 99961261 A 19991223; JP 2000591168 A 19991223