EP 1141339 A1 20011010 - HUMAN FIBROBLAST GROWTH FACTOR RECEPTOR 1 IS A CO-RECEPTOR FOR INFECTION BY ADENO-ASSOCIATED VIRUS 2
Title (en)
HUMAN FIBROBLAST GROWTH FACTOR RECEPTOR 1 IS A CO-RECEPTOR FOR INFECTION BY ADENO-ASSOCIATED VIRUS 2
Title (de)
MENSCHLICHER FIBROBLASTEN-WACHSTUMSFAKTOR-REZEPTOR 1 ALS CO-REZEPTOR ZUR INFEKTION MIT EINEM ADENO-ASSOZIIERTEM VIRUS
Title (fr)
RECEPTEUR HUMAIN DU FACTEUR DE CROISSANCE DES FIBROBLASTES UTILISE COMME CO-RECEPTEUR DANS L'INJECTION DU VIRUS 2 ASSOCIE AUX ADENOVIRUS
Publication
Application
Priority
- US 9931220 W 19991229
- US 11459698 P 19981231
Abstract (en)
[origin: WO0039311A1] The present invention relates generally to the fields of gene therapy. More particularly, it concerns gene transfer using adeno-associated virus and methods of increasing transcription and promoting replication of transgenes. The present invention shows that AAV requires human fibroblast growth factor receptor 1 (FGFR1) as a co-receptor for successful viral entry into the host cell. Methods and compositions for exploiting this finding in AAV vector-mediated gene therapy are disclosed.
IPC 1-7
C12N 15/63; C12N 15/64; C12N 15/864; C12N 15/12; C12N 5/10; A61K 48/00
IPC 8 full level
C12N 15/09 (2006.01); A61K 31/7084 (2006.01); A61K 31/7088 (2006.01); A61K 35/76 (2006.01); A61K 48/00 (2006.01); A61P 1/00 (2006.01); A61P 1/16 (2006.01); A61P 1/18 (2006.01); A61P 7/00 (2006.01); A61P 11/00 (2006.01); A61P 13/08 (2006.01); A61P 13/12 (2006.01); A61P 15/00 (2006.01); A61P 17/00 (2006.01); A61P 19/00 (2006.01); A61P 35/00 (2006.01); C07K 14/71 (2006.01); C12N 15/12 (2006.01); C12N 15/864 (2006.01)
CPC (source: EP)
A61K 48/00 (2013.01); A61P 1/00 (2017.12); A61P 1/16 (2017.12); A61P 1/18 (2017.12); A61P 7/00 (2017.12); A61P 11/00 (2017.12); A61P 13/08 (2017.12); A61P 13/12 (2017.12); A61P 15/00 (2017.12); A61P 17/00 (2017.12); A61P 19/00 (2017.12); A61P 35/00 (2017.12); C07K 14/71 (2013.01); C12N 15/86 (2013.01); C12N 2750/14143 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0039311 A1 20000706; AU 2596400 A 20000731; CA 2358094 A1 20000706; EP 1141339 A1 20011010; EP 1141339 A4 20020417; JP 2002533128 A 20021008
DOCDB simple family (application)
US 9931220 W 19991229; AU 2596400 A 19991229; CA 2358094 A 19991229; EP 99968572 A 19991229; JP 2000591202 A 19991229