EP 1142903 A9 20011205 - BRAIN CELL OR NERVE CELL-PROTECTIVE AGENTS COMPRISING GINSENOSIDE Rb 1?
Title (en)
BRAIN CELL OR NERVE CELL-PROTECTIVE AGENTS COMPRISING GINSENOSIDE Rb 1?
Title (de)
GEHIRN ODER NERVENZELLEN SCHÜTZENDE WIRKSTOFFE DIE GINSENOSID RB1 AUFWEISEN
Title (fr)
AGENTS PROTECTEURS DE CELLULES CEREBRALES OU NERVEUSES CONTENANT DU GINSENOSIDE Rb 1?
Publication
Application
Priority
- JP 9902550 W 19990517
- JP 36556098 A 19981222
Abstract (en)
[origin: WO0037481A1] Preparations for efficaciously administering ginsenoside Rb1 or its salt useful as cell-protective agents. More particularly, medicinal compositions for inhibiting apoptosis or apoptosis-like cell death or medicinal compositions for promoting the expression of a cell death inhibitory gene product Bcl-xL which contain ginsenoside Rb1 or its salt; and preparations for intravenous administration which contain ginsenoside Rb1 or its salt. The above medicinal compositions contain ginsenoside Rb1 or its salt at a low concentration, preferably 1 ng/ml or less and still preferably 1 to 100 fg/ml. These compositions have effects of promoting the expression of the cell death inhibitory gene product Bcl-xL and inhibiting apoptosis or apoptosis-like cell death. The above preparations for intravenous administration are useful in treating or preventing, in particular, brain and nervous diseases.
IPC 1-7
IPC 8 full level
C07J 13/00 (2006.01); A61K 9/08 (2006.01); A61K 31/00 (2006.01); A61K 31/70 (2006.01); A61K 31/7028 (2006.01); A61K 31/7034 (2006.01); A61K 31/704 (2006.01); A61K 31/715 (2006.01); A61P 9/00 (2006.01); A61P 9/02 (2006.01); A61P 9/10 (2006.01); A61P 25/00 (2006.01); A61P 25/02 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 37/00 (2006.01); C07J 17/00 (2006.01)
CPC (source: EP KR US)
A61K 31/70 (2013.01 - KR); A61K 31/704 (2013.01 - EP US); A61P 9/00 (2017.12 - EP); A61P 9/02 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/02 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 37/00 (2017.12 - EP)
Citation (search report)
See references of WO 0037481A1
Designated contracting state (EPC)
CH DE FR GB IT LI
DOCDB simple family (publication)
WO 0037481 A1 20000629; CN 1331698 A 20020116; EP 1142903 A1 20011010; EP 1142903 A4 20020417; EP 1142903 A9 20011205; JP 2000191539 A 20000711; KR 100720970 B1 20070522; KR 20010101218 A 20011114; TW I248361 B 20060201; US 2002002141 A1 20020103; US 6579853 B2 20030617
DOCDB simple family (application)
JP 9902550 W 19990517; CN 99814933 A 19990517; EP 99919615 A 19990517; JP 36556098 A 19981222; KR 20017007448 A 20010615; TW 88118367 A 19991025; US 88739901 A 20010622