EP 1144012 A1 20011017 - LIGAND-PEG POST-COATING STABILIZED LIPOPLEX AND POLYPLEX FOR TARGETED GENE DELIVERY
Title (en)
LIGAND-PEG POST-COATING STABILIZED LIPOPLEX AND POLYPLEX FOR TARGETED GENE DELIVERY
Title (de)
LIPOPLEX UND POLYPLEX STABILISIERTE DURCH LIGAND-PEG POST-COATING FÜR GEZIELTE GENEN-VERABREICHUNG
Title (fr)
LIPOPLEXE ET POLYPLEXE STABILISES SELON UN PROCEDE DE POST-APPLICATION D'UN LIGAND-PEG DANS L'ADMINISTRATION CIBLEE DE GENES
Publication
Application
Priority
- US 0001346 W 20000121
- US 11679299 P 19990121
Abstract (en)
[origin: WO0043043A1] This invention relates to the area of systemic, tissue-specific non-viral gene delivery. The present invention provides a novel method to prepare ligand-directed, PEG-stabilized complex as gene delivery systems for targeted gene therapy. Due to the presence of PEG these novel complexes have longer circulating times than conventional ligand-liposome complexes. In addition, due to the presence of the ligand in the complex with PEG, these complexes are tissue targeting. Their small size further makes them very desirable for in vivo use.
IPC 1-7
IPC 8 full level
A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP)
A61K 47/551 (2017.07); A61K 47/59 (2017.07); A61K 47/60 (2017.07); A61K 47/6911 (2017.07); A61K 47/6935 (2017.07); A61P 35/00 (2017.12)
Citation (search report)
See references of WO 0043043A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0043043 A1 20000727; WO 0043043 B1 20000921; AU 2620000 A 20000807; CA 2358497 A1 20000727; EP 1144012 A1 20011017; JP 2002535290 A 20021022
DOCDB simple family (application)
US 0001346 W 20000121; AU 2620000 A 20000121; CA 2358497 A 20000121; EP 00904440 A 20000121; JP 2000594496 A 20000121