EP 1144435 B1 20060412 - PYROGLUTAMIC ACID DERIVATIVES AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Title (en)
PYROGLUTAMIC ACID DERIVATIVES AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Title (de)
PYROGLUTAMINSÄUREDERIVATE UND DAMIT VERWANDTE VERBINDUNGEN, DIE DIE DURCH VLA-4 VERMITTELTE LEUKOZYTENADHÄSION VERRINGERN
Title (fr)
DERIVES D'ACIDE PYROGLUTAMIQUE ET COMPOSES ASSOCIES, INHIBITEURS DE L'ADHESION LEUKOCYTAIRE A MEDIATION DE VLA-4
Publication
Application
Priority
- US 0001537 W 20000121
- US 23866199 A 19990126
Abstract (en)
[origin: WO0043413A2] Disclosed are pyroglutamic acid derivatives and related compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
IPC 8 full level
A61K 38/00 (2006.01); C07K 5/00 (2006.01); A61P 1/04 (2006.01); A61P 3/10 (2006.01); A61P 9/10 (2006.01); A61P 11/06 (2006.01); A61P 13/12 (2006.01); A61P 17/00 (2006.01); A61P 17/06 (2006.01); A61P 25/28 (2006.01); A61P 27/00 (2006.01); A61P 29/00 (2006.01); A61P 35/04 (2006.01); C07K 5/06 (2006.01); C07K 5/078 (2006.01)
CPC (source: EP)
A61P 1/04 (2018.01); A61P 3/10 (2018.01); A61P 9/10 (2018.01); A61P 11/06 (2018.01); A61P 13/12 (2018.01); A61P 17/00 (2018.01); A61P 17/06 (2018.01); A61P 25/28 (2018.01); A61P 27/00 (2018.01); A61P 29/00 (2018.01); A61P 35/04 (2018.01); C07K 5/06139 (2013.01); C07K 5/06165 (2013.01); C07K 5/06173 (2013.01); C07K 5/06191 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0043413 A2 20000727; WO 0043413 A3 20001130; AR 022405 A1 20020904; AT E323102 T1 20060415; AU 2623800 A 20000807; CA 2358093 A1 20000727; CN 1195773 C 20050406; CN 1344274 A 20020410; DE 60027268 D1 20060524; DE 60027268 T2 20070315; EP 1144435 A2 20011017; EP 1144435 B1 20060412; EP 1612215 A1 20060104; ES 2262504 T3 20061201; HK 1046146 A1 20021227; HK 1046146 B 20050729; JP 2002535341 A 20021022; TW I224110 B 20041121
DOCDB simple family (application)
US 0001537 W 20000121; AR P000100291 A 20000124; AT 00904486 T 20000121; AU 2623800 A 20000121; CA 2358093 A 20000121; CN 00803107 A 20000121; DE 60027268 T 20000121; EP 00904486 A 20000121; EP 05019666 A 20000121; ES 00904486 T 20000121; HK 02106863 A 20020920; JP 2000594829 A 20000121; TW 89101188 A 20000125