EP 1144655 A2 20011017 - REGULATED EXPRESSION USING CONDITIONAL ER RETENTION DOMAINS
Title (en)
REGULATED EXPRESSION USING CONDITIONAL ER RETENTION DOMAINS
Title (de)
REGULIERTE GENEXPRESSION MIT HILFE VON KONDITIONALEN ER RETENTION DOMÄNE
Title (fr)
MATERIAUX ET METHODES IMPLIQUANT DES DOMAINES DE RETENTION CONDITIONNELLE
Publication
Application
Priority
- US 9924327 W 19991019
- US 10474698 P 19981019
- US 17479998 A 19981019
- US 13778799 P 19990602
Abstract (en)
[origin: WO0023602A2] Materials and methods involving conditional retention domains (CRDs) are disclosed. Also disclosed are fusion proteins containing CRDs and cells expressing such fusion proteins. In addition, the invention provides novel methods for producing target proteins in vivo using fusion proteins containing conditional retention domains and methods for identifying novel CRDs.
[origin: WO0023602A2] Materials and methods involving conditional retention domains (CRDs) are disclosed. A conditional retention domain is any domain which is retained in the ER or other secretory compartment in the absence of ligand and is released from the secretory machinery when ligand is bound, i.e. in the presence of ligand. Also disclosed are fusion proteins containing CRDs and cells expressing such fusion proteins. In addition, the invention provides novel methods for producing target proteins in vivo using fusion proteins containing conditional retention domains and methods for identifying novel CRDs.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); C07K 14/47 (2006.01); C07K 14/62 (2006.01); C07K 14/81 (2006.01); C07K 19/00 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/62 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
C07K 14/47 (2013.01); C07K 14/4702 (2013.01); C07K 14/62 (2013.01); C07K 14/811 (2013.01); C12N 15/625 (2013.01); A01K 2217/05 (2013.01); C07K 2319/00 (2013.01); C07K 2319/03 (2013.01); C07K 2319/04 (2013.01); C07K 2319/09 (2013.01); C07K 2319/32 (2013.01); C07K 2319/50 (2013.01); C07K 2319/60 (2013.01); C07K 2319/71 (2013.01); C07K 2319/715 (2013.01); C07K 2319/75 (2013.01); C07K 2319/81 (2013.01); C12N 2799/022 (2013.01)
Citation (search report)
See references of WO 0023602A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0023602 A2 20000427; WO 0023602 A3 20010802; AU 1121000 A 20000508; EP 1144655 A2 20011017; IL 142137 A0 20020310; IL 142137 A 20070704; JP 2002535959 A 20021029
DOCDB simple family (application)
US 9924327 W 19991019; AU 1121000 A 19991019; EP 99955001 A 19991019; IL 14213701 A 20010320; IL 14213799 A 19991019; JP 2000577309 A 19991019