EP 1144667 A2 20011017 - RETROVIRAL EXPRESSION VECTORS ON THE BASIS OF HERV- LONG TERMINAL REPEAT SEQUENCES
Title (en)
RETROVIRAL EXPRESSION VECTORS ON THE BASIS OF HERV- LONG TERMINAL REPEAT SEQUENCES
Title (de)
RETROVIRALE EXPRESSIONSVEKTOREN AUF DER BASIS VON HERV-LTR-SEQUENZEN
Title (fr)
VECTEURS D'EXPRESSION RETROVIRAUX A BASE DE SEQUENCES HERV-LTR (=SEQUENCES NUCLEOTIDIQUES D'ADN A LONGUE REPETITION TERMINALE)
Publication
Application
Priority
- DE 19910650 A 19990310
- EP 0002064 W 20000309
Abstract (en)
[origin: DE19910650A1] The invention relates to retroviral expression vectors with cell-specifically modulatable promotors. The vectors can be used, for example, for the cell-specific expression of therapeutically valuable genes in gene therapy. The invention specifically relates to retroviral expression vectors containing at least the following elements, in a functional configuration: a) DNA sequences for the packaging of the vector RNA and for the cell-specific expression of proteins or peptides which are coded by heterologous DNA nucleotide sequences; b) one or more DNA nucleotide sequences coding for a protein or a peptide and characterized in that for cell-specific expression said DNA sequences contain a cell-specifically modulatable promotor region of a human endogenous retroviral DNA nucleotide sequence (HERV).
IPC 1-7
IPC 8 full level
C12N 7/01 (2006.01); C12N 15/867 (2006.01)
CPC (source: EP)
A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C12N 15/86 (2013.01); C12N 2740/13043 (2013.01)
Citation (search report)
See references of WO 0053789A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
DE 19910650 A1 20000921; EP 1144667 A2 20011017; JP 2002537846 A 20021112; WO 0053789 A2 20000914; WO 0053789 A3 20010405
DOCDB simple family (application)
DE 19910650 A 19990310; EP 0002064 W 20000309; EP 00918779 A 20000309; JP 2000603410 A 20000309