EP 1144997 A2 20011017 - METHODS AND COMPOUNDS FOR MODULATING NUCLEAR RECEPTOR ACTIVITY
Title (en)
METHODS AND COMPOUNDS FOR MODULATING NUCLEAR RECEPTOR ACTIVITY
Title (de)
METHODEN UND VERBINDUNGEN ZUR MODULATION NUKLEARER REZEPTORAKTIVITÄT
Title (fr)
METHODES ET COMPOSES DE MODULATION D'ACTIVITE DE RECEPTEURS NUCLEAIRES
Publication
Application
Priority
- US 9906937 W 19990330
- US 7995698 P 19980330
- US 11314698 P 19981216
- US 11301498 P 19981216
Abstract (en)
[origin: WO9950658A2] The present invention relates to methods and agonist/antagonist compounds for modulating nuclear receptor activity, and nuclear receptor ligand binding. The invention includes a method for identifying residues comprising a ligand binding domain for a nuclear receptor of interest. Also included in a method of identifying agonists and/or antagonists that bind to the ligand binding domain of the nuclear receptors, and the estrogen receptor in particular. The invention is exemplified by identification and manipulation of the ligand binding domain of the estrogen receptor and compounds that bind to this site. The methods can be applied to other nuclear receptors including TR, GR and PR.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 5/14 (2006.01); A61P 9/06 (2006.01); A61P 15/08 (2006.01); A61P 19/10 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01); G06F 17/30 (2006.01)
CPC (source: EP KR)
A61K 31/195 (2013.01 - KR); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 5/14 (2017.12 - EP); A61P 9/06 (2017.12 - EP); A61P 15/08 (2017.12 - EP); A61P 19/10 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07K 14/721 (2013.01 - KR); G01N 33/6875 (2013.01 - EP KR); G01N 33/78 (2013.01 - KR); G01N 2333/723 (2013.01 - KR); G01N 2500/20 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9950658 A2 19991007; WO 9950658 A3 20010816; AU 3457199 A 19991018; CA 2324060 A1 19991007; EP 1144997 A2 20011017; EP 1144997 A3 20020828; JP 2002516983 A 20020611; KR 20010042373 A 20010525
DOCDB simple family (application)
US 9906937 W 19990330; AU 3457199 A 19990330; CA 2324060 A 19990330; EP 99916206 A 19990330; JP 2000541516 A 19990330; KR 20007010940 A 20000930