EP 1145177 B1 20041020 - METHOD AND APPARATUS FOR MONITORING THERAPY EFFECTIVENESS
Title (en)
METHOD AND APPARATUS FOR MONITORING THERAPY EFFECTIVENESS
Title (de)
VERFAHREN UND VORRICHTUNG ZUR BEOBACHTUNG DER THERAPIEEFFEKTIVITÄT
Title (fr)
PROCEDE ET DISPOSITIF DE SURVEILLANCE DE L'EFFICACITE D'UNE THERAPIE AU MOYEN D'UNE TECHNIQUE DE CONVERGENCE EXPONENTIELLE EXECUTEE A L'AIDE DE MESURES DE CHARGE VIRALE D'APRES UN JEU ORDONNE DE MICRO-DEPOTS D'ADN
Publication
Application
Priority
- US 0004079 W 20000217
- US 25379199 A 19990222
Abstract (en)
[origin: WO0051055A2] A technique is described for determining the effectiveness of medical therapy and dosage formulations by analysing dot spectrograms representative of quantized hybridization activity in biological samples, such as DNA, RNA or other protein biomolecular array samples, taken at different sampling times from a patient undergoing the treatment. The technique directly lends itself to disease progression analysis based on markers such as viral load. In accordance with the technique, a viral diffusion curve associated with a therapy of interest is generated and each dot spectrogram is then mapped to the viral diffusion curve using fractal filtering to yield a filtered viral diffusion curve for each sample. A degree of convergence between the filtered viral diffusion curves is determined. Then, a determination is made as to whether the therapy of interest has been effective by determining whether the degree of convergence increases from one sample to another, with an increase in the degree of convergence being representative of a lack of effectiveness of the therapy of interest.
IPC 1-7
IPC 8 full level
G16B 25/10 (2019.01); G06F 19/00 (2011.01)
CPC (source: EP US)
G16B 25/00 (2019.01 - EP US); G16B 25/10 (2019.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0051055 A2 20000831; WO 0051055 A3 20010104; AT E280414 T1 20041115; AU 3494000 A 20000914; DE 60015074 D1 20041125; DE 60015074 T2 20051117; EP 1145177 A2 20011017; EP 1145177 B1 20041020; EP 1406199 A2 20040407; EP 1406199 A3 20061011; US 2003044775 A1 20030306; US 2004072232 A1 20040415; US 6245511 B1 20010612; US 6704662 B2 20040309; US 7047136 B2 20060516
DOCDB simple family (application)
US 0004079 W 20000217; AT 00913502 T 20000217; AU 3494000 A 20000217; DE 60015074 T 20000217; EP 00913502 A 20000217; EP 03028719 A 20000217; US 18988502 A 20020702; US 25379199 A 19990222; US 67740303 A 20031001