Global Patent Index - EP 1146125 A1

EP 1146125 A1 20011017 - Poxvirus with targeted infection specificity

Title (en)

Poxvirus with targeted infection specificity

Title (de)

Pockenviren mit zielgerichteter Infektionsspezifität

Title (fr)

Poxvirus avec spécificité d' infection ciblée

Publication

EP 1146125 A1 20011017 (EN)

Application

EP 01400942 A 20010412

Priority

  • EP 01400942 A 20010412
  • EP 00440109 A 20000414
  • EP 01440009 A 20010122
  • US 24608000 P 20001107

Abstract (en)

The present invention concerns a poxviral particle having a targeted infection specificity conferred by an heterologous ligand moiety present at the surface of said poxviral particle and capable of specifically recognizing and binding to an anti-ligand molecule localized at the surface of target cells. The present invention further relates to a vector comprising a nucleotide sequence encoding a chimeric polypeptide including such an heterologous ligand moiety and all or part of a natural poxviral surface polypeptide. The present invention additionally concerns compositions comprising said poxviral particle or said vector as well as their use for therapeutic and prophylactic purposes. The invention is of very special interest in gene therapy applications, in particular in preventing or treating cancer in mammals. <IMAGE>

IPC 1-7

C12N 15/86; C12N 15/62; C12N 7/04; C07K 14/705; A61K 35/76; A61K 48/00

IPC 8 full level

C12N 15/09 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 39/275 (2006.01); A61K 39/285 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61P 3/10 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61P 43/00 (2006.01); C07K 14/065 (2006.01); C07K 14/07 (2006.01); C07K 14/705 (2006.01); C07K 19/00 (2006.01); C12N 7/00 (2006.01); C12N 7/01 (2006.01); C12N 7/02 (2006.01); C12N 7/04 (2006.01); C12N 15/39 (2006.01); C12N 15/62 (2006.01); C12N 15/63 (2006.01); C12N 15/86 (2006.01); C12N 15/863 (2006.01); C12N 15/869 (2006.01); C12Q 1/70 (2006.01); C12R 1/93 (2006.01)

CPC (source: EP US)

A61K 48/00 (2013.01 - EP); A61P 3/10 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/005 (2013.01 - EP US); C12N 15/86 (2013.01 - EP US); A61K 48/00 (2013.01 - US); C07K 2319/00 (2013.01 - EP); C07K 2319/01 (2013.01 - EP US); C07K 2319/02 (2013.01 - EP); C12N 2710/24122 (2013.01 - EP US); C12N 2710/24143 (2013.01 - EP US); C12N 2710/24145 (2013.01 - EP); C12N 2810/80 (2013.01 - EP US); C12N 2810/859 (2013.01 - EP US); C12N 2830/00 (2013.01 - EP US); C12N 2830/15 (2013.01 - EP US); C12N 2830/60 (2013.01 - EP US); C12N 2840/20 (2013.01 - EP US)

Citation (search report)

  • [Y] WO 9206180 A1 19920416 - UNIV CONNECTICUT [US]
  • [Y] WO 9410323 A1 19940511 - IMP CANCER RES TECH [GB], et al
  • [Y] WO 9427643 A1 19941208 - TARGETED GENETICS CORP [US], et al
  • [Y] WO 0009730 A2 20000224 - UNIV JEFFERSON [US]
  • [XD] GALMICHE MARIE C ET AL: "Expression of a functional single chain antibody on the surface of extracellular enveloped vaccinia virus as a step towards selective tumour cell targeting.", JOURNAL OF GENERAL VIROLOGY, vol. 78, no. 11, November 1997 (1997-11-01), pages 3019 - 3027, XP002173264, ISSN: 0022-1317
  • [Y] RUSSELL S J ET AL: "RETROVIRAL VECTORS DISPLAYING FUNCTIONAL ANTIBODY FRAGMENTS", NUCLEIC ACIDS RESEARCH,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 21, no. 5, 11 March 1993 (1993-03-11), pages 1081 - 1085, XP000616162, ISSN: 0305-1048
  • [Y] MOSS BERNARD: "Genetically engineered poxviruses for recombinant gene expression, vaccination, safety.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 93, no. 21, 1996, 1996, pages 11341 - 11348, XP002173270, ISSN: 0027-8424

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

US 2003165477 A1 20030904; US 7354591 B2 20080408; AT E284970 T1 20050115; AT E411392 T1 20081015; AU 3519001 A 20011018; AU 784776 B2 20060615; CA 2341356 A1 20011014; CA 2341356 C 20111011; CY 1108478 T1 20140409; DE 60107746 D1 20050120; DE 60107746 T2 20051201; DE 60136232 D1 20081127; DK 1146125 T3 20050425; DK 1516932 T3 20081201; EP 1146125 A1 20011017; EP 1146125 B1 20041215; EP 1516932 A1 20050323; EP 1516932 B1 20081015; ES 2232574 T3 20050601; ES 2312918 T3 20090301; JP 2002320475 A 20021105; PT 1146125 E 20050429; PT 1516932 E 20090123

DOCDB simple family (application)

US 83289901 A 20010412; AT 01400942 T 20010412; AT 04077339 T 20010412; AU 3519001 A 20010412; CA 2341356 A 20010410; CY 081101247 T 20081103; DE 60107746 T 20010412; DE 60136232 T 20010412; DK 01400942 T 20010412; DK 04077339 T 20010412; EP 01400942 A 20010412; EP 04077339 A 20010412; ES 01400942 T 20010412; ES 04077339 T 20010412; JP 2001153216 A 20010413; PT 01400942 T 20010412; PT 04077339 T 20010412