EP 1146887 A1 20011024 - GLYCOPEPTIDE ANTIBIOTICS CONTAINING A DESMETHYLVANCOSAMINE RESIDUE, COMBINATORIAL LIBRARIES OF SAME AND METHODS OF PRODUCING SAME
Title (en)
GLYCOPEPTIDE ANTIBIOTICS CONTAINING A DESMETHYLVANCOSAMINE RESIDUE, COMBINATORIAL LIBRARIES OF SAME AND METHODS OF PRODUCING SAME
Title (de)
EINEN DESMETHYLVANCOSAMINREST ENTHALTENDE GLYKOPEPTIDANTIBIOTIKA, KOMBINATORISCHE BIBLIOTHEKEN DERSELBEN UND VERFAHREN ZU DEREN HERSTELLUNG
Title (fr)
ANTIBIOTIQUES A GLYCOPEPTIDE CONTENANT UN RESIDU DESMETHYLVANCOSAMINE, BANQUES COMBINATOIRES ET PROCEDES DE PRODUCTION ASSOCIES
Publication
Application
Priority
- US 0000650 W 20000112
- US 11559499 P 19990112
Abstract (en)
[origin: WO0041710A1] A glycopeptide of the formula A1-A2-A3-A4-A5-A6-A7, in which each dash represents a covalent bond; wherein the group A1 comprises a modified or unmodified alpha -amino acid residue, alkyl, aryl, aralkyl, alkanoyl, aroyl, aralkanoyl, heterocyclic, heterocyclic-carbonyl, heterocyclic-alkyl, heterocyclic-alkyl-carbonyl, akylsulfonyl, arylsulfonyl, guanidinyl, carbamoyl, or xanthyl; wherein each of the groups A2 to A7 comprises a modified or unmodified alpha -amino acid residue, whereby (i) the group A1 is linked to an amino group on the group A2, (ii) each of the groups A2, A4 and A6 bears an aromatic side chain, which aromatic side chains are cross-linked together by two or more covalent bonds, and (iii) the group A7 bears a terminal carboxyl, ester, amide, or N-substituted amide group; and wherein one or more of the groups A1 to A7 is linked via a glycosidic bond to one or more glycosidic groups each having one or more sugar residues; wherein at least one of said sugar residues bears one or more substituents of the formula YXR; provided that: A4 is linked to a glycosidic group comprising a glucose residue substituted only by hydroxyl and/or amino groups and by attachement via a glycosidic bond to formula (II).
IPC 1-7
IPC 8 full level
C07K 9/00 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 9/008 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0041710 A1 20000720; WO 0041710 A9 20011122; AU 2501700 A 20000801; EP 1146887 A1 20011024; EP 1146887 A4 20030507
DOCDB simple family (application)
US 0000650 W 20000112; AU 2501700 A 20000112; EP 00903240 A 20000112