EP 1147203 A1 20011024 - MAMMALIAN SERINE RACEMASE
Title (en)
MAMMALIAN SERINE RACEMASE
Title (de)
SAÜGER-SERIN-RACEMASE
Title (fr)
SERINE RACEMASE DE MAMMIFERE
Publication
Application
Priority
- US 0000938 W 20000118
- US 11633399 P 19990119
- US 14483999 P 19990721
- US 14595399 P 19990728
Abstract (en)
[origin: WO0043526A1] High levels of D-serine occur in mammalian brain, where it appears to be an endogenous ligand of the "glycine site" of NMDA receptors. We have purified from rat brain a soluble enzyme that catalyzes the direct racemization of L-serine to D-serine. Purified serine racemase has a molecular weight of 37 kDa and requires pyridoxal 5'-phosphate for its activity. The enzyme is highly selective toward L-serine, failing to racemize any other amino acid tested. We have also identified polynucleotide sequences which encode mammalian, including human, serine racemase. Compounds which modulate the activity of mammalian serine racemase are useful for treating conditions and diseases which involve overstimulation of NMDA receptors, such as stroke and various neurodegenerative diseases.
IPC 1-7
IPC 8 full level
G01N 33/50 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/90 (2006.01); C12N 15/09 (2006.01); C12N 15/61 (2006.01); C12Q 1/533 (2006.01); G01N 33/15 (2006.01)
CPC (source: EP KR)
C12N 9/90 (2013.01 - EP KR)
Citation (search report)
See references of WO 0043526A1
Citation (examination)
- ATSUSHI HASHIMOTO ET AL.: "Free D-Aspartate and D-Serine in the mammalian brain and periphery", PROGRESS IN NEUROBIOLOGY, vol. 52, 1997, pages 325 - 353
- ANTIMO D'ANIELLO ET AL.: "Biological role of D-amino acid oxidase and D-Aspartate oxidase", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 36, 1993, pages 26941 - 26949
- KAZUHIRO IMAI ET AL.: "Analytical chemistry and biochemistry of D-amino acids", BIOMEDICAL CHROMATOGRAPHY, vol. 10, 1996, pages 303 - 312
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0043526 A1 20000727; AU 2413500 A 20000807; BR 0007592 A 20011106; CA 2360724 A1 20000727; EP 1147203 A1 20011024; HU P0105035 A2 20020429; IL 144102 A0 20020523; JP 2002534984 A 20021022; KR 20010103740 A 20011123; MX PA01007310 A 20020424; NO 20013557 D0 20010718; NO 20013557 L 20010919; PL 364984 A1 20041227; TR 200102081 T2 20011121
DOCDB simple family (application)
US 0000938 W 20000118; AU 2413500 A 20000118; BR 0007592 A 20000118; CA 2360724 A 20000118; EP 00902414 A 20000118; HU P0105035 A 20000118; IL 14410200 A 20000118; JP 2000594934 A 20000118; KR 20017009013 A 20010718; MX PA01007310 A 20000118; NO 20013557 A 20010718; PL 36498400 A 20000118; TR 200102081 T 20000118