EP 1148053 A4 20020306 - 2H-PHTHALAZIN-1-ONE DERIVATIVES AND DRUGS COMPRISING THESE DERIVATIVES AS THE ACTIVE INGREDIENT
Title (en)
2H-PHTHALAZIN-1-ONE DERIVATIVES AND DRUGS COMPRISING THESE DERIVATIVES AS THE ACTIVE INGREDIENT
Title (de)
2H-PHTHALAZIN-1-ON DERIVATE UND DROGENZUSAMMENSETZUNGEN DIE DIESE DERIVATE ALS AKTIVE INHALTSSTOFFE ENTHALTEN
Title (fr)
DERIVES 2H-PHTHALAZINE-1-ONE ET MEDICAMENTS RENFERMANT CES DERIVES COMME PRINCIPE ACTIF
Publication
Application
Priority
- JP 0000319 W 20000124
- JP 1678899 A 19990126
- JP 23309999 A 19990819
Abstract (en)
[origin: WO0044726A1] Poly(ADP-ribose)polymerase inhibitors containing as the active ingredient 2H-phthalazin-1-one derivatives represented by general formula (I) (wherein each symbol is as defined in the description) or salts thereof. The compounds of the general formula (I) inhibit poly(ADP-ribose)polymerase and are useful as preventives and/or remedies for various ischemic diseases (brain, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory intestinal diseases, multiple encephalosclerosis, arthritis, etc.), nerve degeneration diseases (extrapyramidal disorder, Alzheimer's disease, muscular dystrophy, etc.), diabetes, shock, head trauma, renal insufficiency, hyperalgesia, etc. These compounds are also useful as sensitizers for agents against retroviruses (HIV, etc.) and chemotherapy for cancer.
IPC 1-7
C07D 237/32; C07D 401/12; C07D 403/12; C07D 405/12; C07D 409/12; A61K 31/502
IPC 8 full level
A61K 31/502 (2006.01); C07D 237/32 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP KR US)
A61K 31/502 (2013.01 - EP US); C07D 209/18 (2013.01 - KR); C07D 211/62 (2013.01 - KR); C07D 233/64 (2013.01 - KR); C07D 237/32 (2013.01 - EP KR US); C07D 295/13 (2013.01 - KR); C07D 307/14 (2013.01 - KR); C07D 307/52 (2013.01 - KR); C07D 333/20 (2013.01 - KR); C07D 401/12 (2013.01 - EP KR US); C07D 403/12 (2013.01 - EP US); C07D 405/12 (2013.01 - EP KR US); C07D 409/12 (2013.01 - EP KR US); C07D 417/12 (2013.01 - EP US)
Citation (search report)
- [PX] WO 9911624 A1 19990311 - GUILFORD PHARM INC [US]
- [E] WO 0050419 A1 20000831 - BOEHRINGER INGELHEIM PHARMA [DE], et al
- [A] JP S5432489 A 19790309 - DAIICHI SEIYAKU CO
- See references of WO 0044726A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0044726 A1 20000803; AU 3076700 A 20000818; EP 1148053 A1 20011024; EP 1148053 A4 20020306; KR 20010101675 A 20011114; US 6677333 B1 20040113
DOCDB simple family (application)
JP 0000319 W 20000124; AU 3076700 A 20000124; EP 00900889 A 20000124; KR 20017009332 A 20010725; US 88992501 A 20010725