EP 1148885 A1 20011031 - ELECTRICALLY-MEDIATED ENHANCEMENT OF DNA VACCINE IMMUNITY AND EFFICACY IN VIVO
Title (en)
ELECTRICALLY-MEDIATED ENHANCEMENT OF DNA VACCINE IMMUNITY AND EFFICACY IN VIVO
Title (de)
DURCH ELEKTRIZITÄT ERHÖHTE IMMUNITÄT IND WIRKSAMKEIT EINES DNA IMPFSTOFFS
Title (fr)
AUGMENTATION ELECTRIQUEMENT INDUITE DE L'IMMUNITE ET DE L'EFFICACITE DE VACCINS D'ADN IN VIVO
Publication
Application
Priority
- US 0002831 W 20000207
- US 11899699 P 19990208
- US 12918999 P 19990414
Abstract (en)
[origin: WO0045823A1] Electrically-mediated delivery technology has been applied to DNA vaccines and substantially higher immune responses have been achieved. In mice and rabbits vaccinated with DNA encoding HIV genes, when administered with constant electric current or constant electric voltage, up to twenty-fold higher immune responses were achieved compared with application of DNA vaccines alone. The increase was achieved under conditions of both constant current (iontophoresis) and constant voltage (electroporation).
IPC 1-7
IPC 8 full level
A61K 39/00 (2006.01); A61K 39/21 (2006.01); A61K 39/39 (2006.01); A61K 41/00 (2006.01); A61N 1/30 (2006.01); A61N 1/32 (2006.01); A61P 31/00 (2006.01)
CPC (source: EP)
A61K 39/00 (2013.01); A61K 39/12 (2013.01); A61K 39/21 (2013.01); A61K 39/39 (2013.01); A61K 41/00 (2013.01); A61N 1/30 (2013.01); A61N 1/325 (2013.01); A61P 31/00 (2018.01); A61K 2039/53 (2013.01); A61K 2039/575 (2013.01); A61N 1/0424 (2013.01); A61N 1/044 (2013.01); A61N 1/306 (2013.01); C12N 2740/16134 (2013.01); C12N 2740/16234 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0045823 A1 20000810; WO 0045823 A9 20011011; AU 2868200 A 20000825; CA 2361601 A1 20000810; EP 1148885 A1 20011031; EP 1148885 A4 20020508
DOCDB simple family (application)
US 0002831 W 20000207; AU 2868200 A 20000207; CA 2361601 A 20000207; EP 00907132 A 20000207