Global Patent Index - EP 1148885 A4

EP 1148885 A4 20020508 - ELECTRICALLY-MEDIATED ENHANCEMENT OF DNA VACCINE IMMUNITY AND EFFICACY IN VIVO

Title (en)

ELECTRICALLY-MEDIATED ENHANCEMENT OF DNA VACCINE IMMUNITY AND EFFICACY IN VIVO

Title (de)

DURCH ELEKTRIZITÄT ERHÖHTE IMMUNITÄT IND WIRKSAMKEIT EINES DNA IMPFSTOFFS

Title (fr)

AUGMENTATION ELECTRIQUEMENT INDUITE DE L'IMMUNITE ET DE L'EFFICACITE DE VACCINS D'ADN IN VIVO

Publication

EP 1148885 A4 20020508 (EN)

Application

EP 00907132 A 20000207

Priority

  • US 0002831 W 20000207
  • US 11899699 P 19990208
  • US 12918999 P 19990414

Abstract (en)

[origin: WO0045823A1] Electrically-mediated delivery technology has been applied to DNA vaccines and substantially higher immune responses have been achieved. In mice and rabbits vaccinated with DNA encoding HIV genes, when administered with constant electric current or constant electric voltage, up to twenty-fold higher immune responses were achieved compared with application of DNA vaccines alone. The increase was achieved under conditions of both constant current (iontophoresis) and constant voltage (electroporation).

IPC 1-7

A61K 31/70; A61K 45/00; A61N 1/30; A61N 1/00; C12M 1/42

IPC 8 full level

A61K 39/00 (2006.01); A61K 39/21 (2006.01); A61K 39/39 (2006.01); A61K 41/00 (2006.01); A61N 1/30 (2006.01); A61N 1/32 (2006.01); A61P 31/00 (2006.01)

CPC (source: EP)

A61K 39/00 (2013.01); A61K 39/12 (2013.01); A61K 39/21 (2013.01); A61K 39/39 (2013.01); A61K 41/00 (2013.01); A61N 1/30 (2013.01); A61N 1/325 (2013.01); A61P 31/00 (2018.01); A61K 2039/53 (2013.01); A61K 2039/575 (2013.01); A61N 1/0424 (2013.01); A61N 1/044 (2013.01); A61N 1/306 (2013.01); C12N 2740/16134 (2013.01); C12N 2740/16234 (2013.01)

Citation (search report)

  • [X] WO 9843702 A2 19981008 - MATHIESEN IACOB [NO], et al
  • [PX] WO 9936563 A1 19990722 - EMED CORP [US]
  • [X] WO 9901157 A1 19990114 - RHONE POULENC RORER SA [FR], et al
  • [X] WO 9901175 A1 19990114 - RHONE POULENC RORER SA [FR], et al
  • [X] WO 9904850 A1 19990204 - EMED CORP [US]
  • [X] WO 9639531 A1 19961212 - MASSACHUSETTS INST TECHNOLOGY [US]
  • [X] MASAYUKI NOMURA ET AL: "IN VIVO INDUCTION OF CYTOTOXIC T LYMPHOCYTES SPECIFIC FOR A SINGLE EPITOPE INTRODUCED INTO AN UNRELATED MOLECULE", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 193, 1996, pages 41 - 49, XP002928836, ISSN: 0022-1759
  • [X] ABE ET AL: "A novel gene transfer method in vivo: The pulse electric field gene transfer (PEFGT)", GENE THERAPY, vol. 2, no. 9, November 1995 (1995-11-01), pages 694, XP001056944
  • [A] BANGA AJAY K ET AL: "Iontophoresis and electroporation: Comparisons and contrasts.", INTERNATIONAL JOURNAL OF PHARMACEUTICS (AMSTERDAM), vol. 179, no. 1, 1 March 1999 (1999-03-01), pages 1 - 19, XP002192323, ISSN: 0378-5173
  • [A] VANBEVER R ET AL: "IN VIVO EFFICACY AND SAFETY OF SKIN ELECTROPORATION", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, vol. 35, no. 1, 1999, pages 77 - 78, XP001057033, ISSN: 0169-409X
  • See also references of WO 0045823A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0045823 A1 20000810; WO 0045823 A9 20011011; AU 2868200 A 20000825; CA 2361601 A1 20000810; EP 1148885 A1 20011031; EP 1148885 A4 20020508

DOCDB simple family (application)

US 0002831 W 20000207; AU 2868200 A 20000207; CA 2361601 A 20000207; EP 00907132 A 20000207