EP 1149103 A1 20011031 - THIENYLBENZOYLBENZAZEPINES AS VASOPRESSIN AGONISTS
Title (en)
THIENYLBENZOYLBENZAZEPINES AS VASOPRESSIN AGONISTS
Title (de)
THIENYLBENZOYLBENZAZEPINE ALS VASOPRESSINANTAGONISTEN
Title (fr)
THIENYLBENZOYLBENZAZEPINES UTILISEES EN TANT QU'AGONISTES DE LA VASOPRESSINE
Publication
Application
Priority
- US 0000358 W 20000107
- US 24417999 A 19990204
Abstract (en)
[origin: WO0046227A1] The present invention provides compounds of general formula: (I) wherein Y is a moiety selected independently, from NH OR -(CH2)<n>- wherein n is 1; m is an integer from 1 to 2; and the moiety (a) represents: (1) a 5-membered aromatic (unsaturated) heterocyclic ring having one nitrogen (wherein A is nitrogen, and B and C are CH), (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen (wherein A is carbon, B is nitrogen, and C is -CH-CH-), (3) a 6-membered aromatic (unsaturated) ring (wherein A is carbon, B is CH, and C is -CH-CH-); as well as methods and pharmaceutical compositions utilizing these compounds for the treatment of disorder which may be remedied or alleviated by vasopressin agonist activity, including diabetes insipidus noctural enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, or temporary delay of urination.
IPC 1-7
IPC 8 full level
C07D 487/04 (2006.01); A61K 31/55 (2006.01); A61K 31/5513 (2006.01); A61K 31/5517 (2006.01); A61P 7/04 (2006.01); A61P 7/12 (2006.01); A61P 13/02 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP)
A61P 7/04 (2017.12); A61P 7/12 (2017.12); A61P 13/02 (2017.12); A61P 43/00 (2017.12); C07D 471/04 (2013.01); C07D 487/04 (2013.01)
Citation (search report)
See references of WO 0046227A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated extension state (EPC)
AL LT LV RO SI
DOCDB simple family (publication)
WO 0046227 A1 20000810; AR 028470 A1 20030514; AU 2603000 A 20000825; CA 2358891 A1 20000810; CN 1339036 A 20020306; EP 1149103 A1 20011031; JP 2002536377 A 20021029
DOCDB simple family (application)
US 0000358 W 20000107; AR P000100462 A 20000203; AU 2603000 A 20000107; CA 2358891 A 20000107; CN 00803456 A 20000107; EP 00904244 A 20000107; JP 2000597297 A 20000107