EP 1150673 A1 20011107 - MONO-ACYLOXY ARALKYL NEUROMUSCULAR RELAXANTS
Title (en)
MONO-ACYLOXY ARALKYL NEUROMUSCULAR RELAXANTS
Title (de)
MONOACYLOXY-ARALKYLVERBINDUNGEN MIT MUSKELRELAXIERENDER WIRKUNG
Title (fr)
RELAXANTS NEUROMUSCULAIRES MONO-ACYLOXY ARALKYLES
Publication
Application
Priority
- US 0002228 W 20000131
- US 11839299 P 19990201
Abstract (en)
[origin: WO0044377A1] Mono-acyloxy substituted aralkyl and aralkenyl bis-quaternary ammonium derivatives of cyclic alkanol diesters according to general Formula (a) or (b), where R1 and R1' are mono-acyloxy subst ituted aralkyl or aralkenyl; R2 and R2' are alkyl or alkenyl; A is normal or substituted alkanedicarbonyl, alkenedicarbonyl, alkynedicarbonyl, cycloalkanedicarbonyl, cycloalkenedicarbonyl, bicycloalkanedicarbonyl, bicycloalkenedicarbonyl, polycycloalkanedicarbonyl, polycycloalkenedicarbonyl or aromatic dicarbonyl; n is 0, 1, or 2; m is 0, 1, or 2; p is 0, 1, or 2; R3 and R3' are H, CH3, or lower alkyl; R4 and R4' are H, CH3, or lower alkyl; R3 and R4 together can also be -CH=CH-, -(CH2)h-Y-(CH2)k-, or (1), where Y is CH2, O or S, h is 0, 1, 2 or 3, k is 0, 1, 2 or 3; and R3' and R4' together can also be -CH=CH-, -(CH2)h-Y-(CH2)k-, or (1), where Y is CH2, O or S, h is 0, 1, 2 or 3, k is 0, 1, 2 or 3; wherein R1 and R1', R2 and R2', R3 and R3', and R4 and R4' can be the same or different; and X is a pharmaceutically acceptable anion; have advantageous neuromuscular relaxant properties.
IPC 1-7
A61K 31/397; A61K 31/403; A61K 31/439; A61K 31/454; A61K 31/4025; A61K 31/4545; A61K 31/55; C07D 211/46; C07D 223/08; C07D 295/04; C07D 401/02; C07D 401/12; C07D 403/12; C07D 453/02; C07D 487/00; C07D 487/08
IPC 8 full level
A61K 31/439 (2006.01); A61P 21/02 (2006.01); C07D 211/46 (2006.01); C07D 519/00 (2006.01)
CPC (source: EP KR)
A61K 31/439 (2013.01 - KR); A61P 21/02 (2018.01 - EP); C07D 211/46 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0044377 A1 20000803; AR 022472 A1 20020904; AU 2634900 A 20000818; BR 0007863 A 20011106; CA 2360790 A1 20000803; CN 1338934 A 20020306; CO 5170470 A1 20020627; CZ 20012780 A3 20020116; EP 1150673 A1 20011107; EP 1150673 A4 20020424; HK 1039455 A1 20020426; HU P0200413 A2 20020629; HU P0200413 A3 20021128; IL 144249 A0 20020523; JP 2002535366 A 20021022; KR 20010108125 A 20011207; MX PA01007783 A 20020820; NO 20013741 D0 20010731; NO 20013741 L 20010919; NZ 513064 A 20030829; PE 20001593 A1 20010116; PL 349099 A1 20020701; TR 200102196 T2 20020121; ZA 200105882 B 20030218
DOCDB simple family (application)
US 0002228 W 20000131; AR P000100432 A 20000201; AU 2634900 A 20000131; BR 0007863 A 20000131; CA 2360790 A 20000131; CN 00803305 A 20000131; CO 00005913 A 20000201; CZ 20012780 A 20000131; EP 00904621 A 20000131; HK 02100995 A 20020208; HU P0200413 A 20000131; IL 14424900 A 20000131; JP 2000595680 A 20000131; KR 20017009305 A 20010725; MX PA01007783 A 20000131; NO 20013741 A 20010731; NZ 51306400 A 20000131; PE 0000692000 A 20000131; PL 34909900 A 20000131; TR 200102196 T 20000131; ZA 200105882 A 20010717