EP 1150701 A2 20011107 - HOMING PRO-APOPTOTIC CONJUGATES AND METHODS OF USING SAME
Title (en)
HOMING PRO-APOPTOTIC CONJUGATES AND METHODS OF USING SAME
Title (de)
ZIELANSTEUERNDE PRO-APOPTOTISCHE KONJUGATE UND METHODEN ZU DEREN VERWENDUNG
Title (fr)
CONJUGUES PRO-APOPTOTIQUES DE DOMICILIATION ET LEURS METHODES D'UTILISATION
Publication
Application
Priority
- US 0001602 W 20000121
- US 23590299 A 19990122
Abstract (en)
[origin: WO0042973A2] The present invention provides a homing pro-apoptotic conjugate, which includes a tumor homing molecule that selectively homes to a selected mammalian cell type or tissue linked to an antimicrobial peptide, where the conjugate is selectively internalized by the mammalian cell type or tissue and exhibits high toxicity thereto, and where the antimicrobial peptide has low mammalian cell toxicity when not linked to the tumor homing molecule. A homing pro-apoptotic conjugate of the invention can be, for example, CNGRC-GG-D(KLAKLAK)2 or ACDCRGDCFC-GG-D(KLAKLAK)2. The conjugates of the invention are useful, for example, for treating a patient with a tumor having angiogenic vasculature.
IPC 1-7
A61K 38/00; A61K 38/04; A61K 39/00; A61K 39/02; C07K 14/00; C07K 16/00; C07K 17/00; C07K 2/00; C07K 4/00; C07K 5/00; C07K 7/00
IPC 8 full level
A61K 38/00 (2006.01); A61K 47/48 (2006.01); A61P 13/08 (2006.01); A61P 35/00 (2006.01); C07K 7/00 (2006.01); C07K 14/00 (2006.01)
CPC (source: EP)
A61K 47/62 (2017.07); A61P 13/08 (2017.12); A61P 35/00 (2017.12)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0042973 A2 20000727; WO 0042973 A3 20000928; AU 3348600 A 20000807; AU 770381 B2 20040219; CA 2359633 A1 20000727; EP 1150701 A2 20011107; EP 1150701 A4 20030326; JP 2002535258 A 20021022; JP 4531267 B2 20100825
DOCDB simple family (application)
US 0001602 W 20000121; AU 3348600 A 20000121; CA 2359633 A 20000121; EP 00911617 A 20000121; JP 2000594432 A 20000121