Global Patent Index - EP 1150939 A4

EP 1150939 A4 20030326 - NEPHRONIN: A SERIES OF COMPOUNDS FOR TREATMENT OF INFECTIOUS DISEASES AND CANCER

Title (en)

NEPHRONIN: A SERIES OF COMPOUNDS FOR TREATMENT OF INFECTIOUS DISEASES AND CANCER

Title (de)

NEPHRONIN: EINE REIHE VON VERBINDUNGEN ZUR BEHANDLUNG VON INFEKTIONSKRANKHEITEN UND KREBS

Title (fr)

NEPHRONINE: SERIE DE COMPOSES DESTINES AU TRAITEMENT DE MALADIES INFECTIEUSES ET DU CANCER

Publication

EP 1150939 A4 20030326 (EN)

Application

EP 99966796 A 19991221

Priority

  • AU 9901157 W 19991221
  • AU PP784998 A 19981221

Abstract (en)

[origin: WO0037421A1] The present invention provides a non-proteinaceous compound isolatable from the urine of patients suffering from steroid responsive nephrotic syndrome. The compound has the following characterising features; (i) a molecular weight less than 1 KDa; (ii) binds specifically to heparin and heparan sulphate but not other glycosaminoglycans; and (iii) inhibits LPS induced production of TNF- alpha and/or IL-1 alpha . The present invention also provides a compound of general formula: (I) in which l, m and n may be the same or different and integers of 0 to 10; and X is R-CO-O-, R-O-PO2-O-, R-O-SO2-O-, R-CO-NH-, R-CO-, R-O- or monosaccharide or oligosaccharide including amide substituted saccharides; in which R is a saturated, unsaturated, branched or cyclic carbon chain of up to 32 carbon atoms which optionally contains one or more hydroxyl groups, carbonyl groups, carboxylic acids groups, amino groups, phosphate groups or sulphate groups or combination thereof; and pharmaceutically acceptable salts and derivatives thereof.

IPC 1-7

C07C 69/003

IPC 8 full level

A61K 31/7024 (2006.01); A61K 31/215 (2006.01); A61K 31/225 (2006.01); A61K 33/42 (2006.01); A61K 35/22 (2006.01); A61P 31/04 (2006.01); A61P 31/12 (2006.01); A61P 31/18 (2006.01); A61P 31/22 (2006.01); A61P 35/00 (2006.01); C07C 69/675 (2006.01); C07C 69/704 (2006.01); C07C 305/08 (2006.01); C07F 9/09 (2006.01)

CPC (source: EP)

A61K 31/225 (2013.01); A61P 31/04 (2017.12); A61P 31/12 (2017.12); A61P 31/18 (2017.12); A61P 31/22 (2017.12); A61P 35/00 (2017.12); C07C 69/675 (2013.01); C07C 69/704 (2013.01); C07C 305/08 (2013.01); C07F 9/091 (2013.01)

Citation (search report)

  • [X] DE 193767 C
  • [X] WO 9505154 A1 19950223 - UNILEVER PLC [GB], et al
  • [X] US 2636887 A 19530428 - SCHWAB ARTHUR W, et al
  • [X] US 2766145 A 19561009 - O'BRIEN JONES SAMUEL
  • [X] WO 9639095 A1 19961212 - YISSUM RES DEV CO [IL]
  • [X] WO 9846217 A1 19981022 - YU RUEY J [US], et al
  • [X] US 4962208 A 19901009 - GLOBUS ALFRED R [US]
  • [X] DE 2411479 A1 19740919 - KAO CORP
  • [X] US 3929887 A 19751230 - FLIEDNER JR LEONARD J, et al
  • [X] EP 0035742 A1 19810916 - MICROBIAL CHEM RES FOUND [JP]
  • [A] WO 9426263 A2 19941124 - WELLCOME FOUND [GB], et al
  • [X] DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002227121, retrieved from STN Database accession no. 1993:87624 & JP H04202140 A 19920722 - SEKISUI CHEMICAL CO LTD
  • [X] DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002227122, retrieved from STN Database accession no. 1982:564032 & JP S5773050 A 19820507 - MUSASHINO KAGAKU KENKYUSHO
  • [X] DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002227123, retrieved from STN Database accession no. 1997:203712 & JP H0913065 A 19970114 - KAO CORP
  • [X] DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002227124, retrieved from STN Database accession no. 1981:17408 & Y. ABE ET AL, YUKAGAKU, vol. 29, no. 10, 1980, pages 748 - 754
  • [X] G.R. NEWKOME ET AL, J. ORG. CHEM., vol. 56, no. 25, 1991, pages 7162 - 7167, XP002227120
  • [X] J.L. GABRIEL ET AL, J. BIOL. CHEM., vol. 259, no. 3, 1984, pages 1622 - 1628, XP000943913
  • [X] DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002227125, retrieved from STN Database accession no. 1996:410478 & IN 173592 A
  • [X] DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002227126, retrieved from STN Database accession no. 1968:452756 & JP S438621 B1
  • See references of WO 0037421A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0037421 A1 20000629; AU PP784998 A0 19990121; CA 2355840 A1 20000629; EP 1150939 A1 20011107; EP 1150939 A4 20030326; JP 2002533317 A 20021008

DOCDB simple family (application)

AU 9901157 W 19991221; AU PP784998 A 19981221; CA 2355840 A 19991221; EP 99966796 A 19991221; JP 2000589493 A 19991221