EP 1150956 A1 20011107 - NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
Title (en)
NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
Title (de)
NICHTNUKLEOSIDE REVERSE TRANSKRIPTASE INHIBITOREN
Title (fr)
INHIBITEURS NON NUCLEOSIDIQUES DE LA TRANSCRIPTASE INVERSE
Publication
Application
Priority
- SE 9901403 W 19990818
- SE 9900194 W 19990215
- US 24931799 A 19990212
Abstract (en)
[origin: CA2362135A1] Non-nucleoside reverse transcriptase inhibitors of formula (P-1) wherein: Ar 1 is an unsaturated, optionally substituted, mono or bicyclic ring structure comprising 0 to 3 hetero atoms selected from S, O and N; Ar2 is an aromatic, optionally substituted, monocyclic ring structure comprising at least one nitrogen hetero atom and zero to two further hetero atoms selected from S, O and N; R4 and R5 are independently H or C3-C8 cycloalkyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C8 alkynyl, C1-C5 alkoxy, C1-C4 alkanoyloxy, C1-C4 alkylthio, amino, carboxy, carbamoyl, cyano, halo, hydroxy, aminomethyl, hydroxymethyl, carboxymethyl, or halo substituted C1-C6 alkyl mercapto, nitro; or R4 and R5 join to form a 3-6 membered, optionally substituted ring structure; R6 is O or S; Rx is the residue of a natural or unnatural amino acid; and L* is a linke r moiety which is ether-, carbonate- or ester-bound to the adjacent oxygen and ester linked to Rx; and pharmaceutically acceptable salts thereof are anti-H IV agents with favourable pharmacokinetic properties.
IPC 1-7
IPC 8 full level
A61K 31/44 (2006.01); C07D 213/85 (2006.01)
Citation (search report)
See references of WO 0047561A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
AU 5665899 A 20000829; AU 770801 B2 20040304; CA 2362135 A1 20000817; EP 1150956 A1 20011107
DOCDB simple family (application)
AU 5665899 A 19990818; CA 2362135 A 19990818; EP 99943591 A 19990818