EP 1150997 A1 20011107 - COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Title (en)
COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Title (de)
INHIBIERENDE VERBINDUNGEN DER VLA-4-INDUZIERTEN LEUKOZYTEN ADHÄSION
Title (fr)
COMPOSES INHIBANT L'ADHESION DES LEUCOCYTAIRE PROVOQUEE PAR VLA-4
Publication
Application
Priority
- US 0001603 W 20000121
- US 23747399 A 19990125
Abstract (en)
[origin: WO0043415A1] Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
IPC 1-7
IPC 8 full level
C07D 401/04 (2006.01); A61K 31/40 (2006.01); A61K 31/41 (2006.01); A61K 31/454 (2006.01); A61P 1/00 (2006.01); A61P 3/10 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01); A61P 19/00 (2006.01); A61P 19/02 (2006.01); A61P 25/00 (2006.01); A61P 25/28 (2006.01); A61P 27/04 (2006.01); A61P 29/00 (2006.01); A61P 35/04 (2006.01); A61P 37/00 (2006.01); C07D 207/08 (2006.01); C07D 207/09 (2006.01); C07D 207/48 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07K 5/023 (2006.01); C07K 5/06 (2006.01); C07K 5/065 (2006.01); C07K 5/078 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 1/00 (2017.12); A61P 3/10 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 19/00 (2017.12); A61P 19/02 (2017.12); A61P 25/00 (2017.12); A61P 25/28 (2017.12); A61P 27/04 (2017.12); A61P 29/00 (2017.12); A61P 35/04 (2017.12); A61P 37/00 (2017.12); C07D 207/48 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07K 5/06026 (2013.01); C07K 5/06078 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 0043415A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0043415 A1 20000727; AR 029611 A1 20030710; AU 3348700 A 20000807; CA 2359114 A1 20000727; CN 1185250 C 20050119; CN 1340058 A 20020313; EP 1150997 A1 20011107; HK 1044549 A1 20021025; HK 1044549 B 20050527; JP 2002539080 A 20021119; MX PA01007394 A 20020409
DOCDB simple family (application)
US 0001603 W 20000121; AR P000100290 A 20000124; AU 3348700 A 20000121; CA 2359114 A 20000121; CN 00803103 A 20000121; EP 00911618 A 20000121; HK 02106216 A 20020823; JP 2000594831 A 20000121; MX PA01007394 A 20000121