EP 1151002 A1 20011107 - ANTIBODIES SPECIFIC TO KDR AND USES THEREOF
Title (en)
ANTIBODIES SPECIFIC TO KDR AND USES THEREOF
Title (de)
ANTIKÖRPER SPEZIFISCH FÜR KDR UND IHRE VERWENDUNGEN
Title (fr)
ANTICORPS SPECIFIQUES AU KDR ET LEURS UTILISATIONS
Publication
Application
Priority
- US 0002180 W 20000128
- US 24073699 A 19990129
- US 11772699 P 19990129
Abstract (en)
[origin: WO0044777A1] The invention provides an immunoglobulin molecule which binds SI(KDR) with an affinity comparable to human VEGF, and that neutralizes activation of KDR. Immunoglobulin molecules include monovalent single chain antibodies, multivalent single chain antibodies, diabodies, triabodies, antibodies, humanized antibodies and chimerized antibodies. The invention further provides nucleic acid molecules that encode these immunoglobulin molecules. The invention also provides a method of making the immunoglobulin molecules mentioned above. The invention further provides a method of neutralizing the activation of KDR, a method of inhibiting angiogenesis in a mammal and a method of inhibiting tumor growth in a mammal with such immunoglobulin molecules.
IPC 1-7
C07K 14/00; C07K 16/00; C07K 16/28; C12N 15/11; C12N 15/00; A61K 39/395
IPC 8 full level
C12N 15/09 (2006.01); A61K 39/395 (2006.01); A61P 7/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 16/28 (2006.01); C07K 16/46 (2006.01); C12P 21/02 (2006.01)
CPC (source: EP)
A61P 7/00 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 16/2863 (2013.01); C07K 2317/24 (2013.01); C07K 2317/622 (2013.01); C07K 2317/626 (2013.01); C07K 2319/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0044777 A1 20000803; AU 3475100 A 20000818; CA 2361553 A1 20000803; CN 1345334 A 20020417; EP 1151002 A1 20011107; EP 1151002 A4 20020502; IL 144578 A0 20020523; JP 2002536968 A 20021105
DOCDB simple family (application)
US 0002180 W 20000128; AU 3475100 A 20000128; CA 2361553 A 20000128; CN 00805856 A 20000128; EP 00913280 A 20000128; IL 14457800 A 20000128; JP 2000596033 A 20000128