EP 1151099 A1 20011107 - HORMONE-HORMONE RECEPTOR COMPLEXES AND NUCLEIC ACID CONSTRUCTS AND THEIR USE IN GENE THERAPY
Title (en)
HORMONE-HORMONE RECEPTOR COMPLEXES AND NUCLEIC ACID CONSTRUCTS AND THEIR USE IN GENE THERAPY
Title (de)
HORMON-HORMONREZEPTORKOMPLEXE UND NUCLEINSÄUREKONSTRUKTE UND IHRE VERWENDUNG IN DER GENTHERAPIE
Title (fr)
COUPLES HORMONE-RECEPTEUR HORMONAL, CONSTRUCTIONS D'ACIDES NUCLEIQUES, ET UTILISATION DE CEUX-CI EN THERAPIE GENIQUE
Publication
Application
Priority
- DE 19907099 A 19990219
- EP 0001368 W 20000218
- US 12084899 P 19990219
Abstract (en)
[origin: WO0049147A1] The invention relates to the use of a nucleic acid contruct comprising at least one hormone responsive element and a transgene for preparing an agent for gene transfer. It further relates to particular nucleic acid contructs comprising at least one hormone responsive element and a transgene, wherein one of said at least one hormone responsive elements is not functionally linked to the transgene, vectors comprising such nucleic acid contructs and compositions of matter comprising such nucleic acid constructs wherein the hormone responsive elements of the constructs are coupled to a hormone-hormone receptor complex. The nucleic acid constructs, plasmids, and compositions of matter of the invention have applications in gene therapy, particularly in the treatment of human blood clotting disorders, such as hemophilia. They may also be used to up- or down-regulate target genes and for the delivery of vaccines.
IPC 1-7
C12N 15/12; C12N 15/57; C12N 15/67; C12N 15/85; C12N 9/64; C07K 14/72; C12Q 1/68; A61K 48/00
IPC 8 full level
A01K 67/027 (2006.01); A01K 67/033 (2006.01); A61K 31/7115 (2006.01); A61K 38/00 (2006.01); A61K 38/43 (2006.01); A61K 47/46 (2006.01); A61K 48/00 (2006.01); A61P 7/04 (2006.01); A61P 11/00 (2006.01); A61P 35/00 (2006.01); C07K 14/72 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/64 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12N 15/85 (2006.01)
CPC (source: EP)
A61K 48/00 (2013.01); A61P 7/04 (2017.12); A61P 11/00 (2017.12); A61P 35/00 (2017.12); C07K 14/721 (2013.01); C12N 9/644 (2013.01); C12N 15/85 (2013.01); C12Y 304/21022 (2013.01); C07K 2319/00 (2013.01); C12N 2830/30 (2013.01); C12N 2830/42 (2013.01)
Citation (search report)
See references of WO 0049147A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0049147 A1 20000824; AU 2005200908 A1 20050324; AU 2806100 A 20000904; AU 780854 B2 20050421; CA 2362970 A1 20000824; EP 1151099 A1 20011107; JP 2002537311 A 20021105; NZ 513595 A 20010928
DOCDB simple family (application)
EP 0001368 W 20000218; AU 2005200908 A 20050228; AU 2806100 A 20000218; CA 2362970 A 20000218; EP 00906356 A 20000218; JP 2000599872 A 20000218; NZ 51359500 A 20000218