EP 1152774 A2 20011114 - BIOCOMPATIBLE MATERIAL WITH A NOVEL FUNCTIONALITY
Title (en)
BIOCOMPATIBLE MATERIAL WITH A NOVEL FUNCTIONALITY
Title (de)
BIOVERTRÄGLICHES MATERIAL MIT EINER NEUEN FUNKTIONALITÄT
Title (fr)
MATERIAU BIOCOMPATIBLE AVEC UNE NOUVELLE FONCTIONNALITE
Publication
Application
Priority
- DK 0000065 W 20000217
- DK PA199900210 A 19990217
Abstract (en)
[origin: WO0048642A2] The present invention is in the area of biomaterials, i.e. materials that are used in contact with living tissue and biological fluids for prosthetical, therapeutical, storage and the like. In particular, the invention relates to a novel approach of creating biocompatible surfaces, said surfaces being capable of functionally interacting with biological material. Said biocompatible surfaces comprise at least two components, such as a hydrophobic substratum and a macromolecule of hydrophilic nature, that cooperatively form a novel biocompatible surface. The novel approach is based on contacting said hydrophobic substratum with a laterally patterned monomolecular layer of hydrophilic and flexible macromolecules that exhibit a pronounced excluded volume. The surface is, in respect to polarity and morphology, a molecularly heterogeneous surface. Structural features of said macromolecular monolayer (as e.g. the layer thickness or its lateral density) are determined by, i) the structural features of the layer forming macromolecules (as e.g. their MW or their molecular architecture) and, ii) the method of creating said monomolecular layer (as e.g. by physi- or chemisorbing, or by chemically binding said macromolecules). The structural features of the layer forming macromolecule(s) is in turn determined by synthesis.
IPC 1-7
IPC 8 full level
A61K 9/00 (2006.01); A61L 27/00 (2006.01); A61L 27/34 (2006.01); A61L 29/08 (2006.01); A61L 31/10 (2006.01); C12N 5/00 (2006.01)
CPC (source: EP)
A61K 9/0024 (2013.01); A61L 27/34 (2013.01); A61L 29/085 (2013.01); A61L 31/10 (2013.01); B82Y 5/00 (2013.01); B82Y 30/00 (2013.01); C12N 5/0068 (2013.01); C12N 2533/30 (2013.01)
Citation (search report)
See references of WO 0048642A2
Citation (examination)
- US 5889073 A 19990330 - ZHANG HUSHENG [JP], et al
- GB 2325467 A 19981125 - DAINIPPON INK & CHEMICALS [JP], et al
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0048642 A2 20000824; WO 0048642 A3 20001221; WO 0048642 B1 20010222; AU 2536600 A 20000904; EP 1152774 A2 20011114; JP 2002537025 A 20021105
DOCDB simple family (application)
DK 0000065 W 20000217; AU 2536600 A 20000217; EP 00903567 A 20000217; JP 2000599431 A 20000217