Global Patent Index - EP 1155056 A4

EP 1155056 A4 20040512 - METHOD FOR THE IMMOBILIZATION OF OLIGONUCLEOTIDES

Title (en)

METHOD FOR THE IMMOBILIZATION OF OLIGONUCLEOTIDES

Title (de)

VERFAHREN ZUR IMMOBILISIERUNG VON OLIGONUCLEOTIDEN

Title (fr)

METHODE D'IMMOBILISATION D'OLIGONUCLEOTIDES

Publication

EP 1155056 A4 20040512 (EN)

Application

EP 99960649 A 19991203

Priority

  • US 9928666 W 19991203
  • US 11089198 P 19981204

Abstract (en)

[origin: WO0034343A1] Novel compositions are provided for introducing into a cell, a nucleic acid molecule capable of modulating the genotype and phenotype. The gene can be introduced into a mammalian host by way of an expression vector either as naked DNA or conjugated to carriers, particularly cationic carriers. The conjugation is accomplished by means of an ethylene-containing moiety tethered to the nucleic acid molecule. The techniques and compositions find use in the palliation or treatment of any of a variety of genetic-based disorders.

IPC 1-7

C12N 15/87; C07H 21/00; A61K 47/48; A61K 48/00; C12Q 1/68

IPC 8 full level

C12N 15/87 (2006.01)

CPC (source: EP)

C12N 15/87 (2013.01)

Citation (search report)

  • [X] WO 9839351 A1 19980911 - MOSAIC TECHNOLOGIES INC [US]
  • [X] WO 9814615 A1 19980409 - ISIS PHARMACEUTICALS INC [US]
  • [X] EP 0524864 A1 19930127 - BIO MERIEUX [FR]
  • [X] US 5658731 A 19970819 - SPROAT BRIAN [DE], et al
  • [A] WO 9114696 A1 19911003 - GILEAD SCIENCES INC [US]
  • [DX] NAGATSUGI F ET AL: "2-Aminopurine Derivatives with C6-Substituted Olefin as Novel Cross-Linking Agents and the Synthesis of the Corresponding beta-Phosphoramidite Precursors", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 53, no. 9, 3 March 1997 (1997-03-03), pages 3035 - 3044, XP004105389, ISSN: 0040-4020
  • [X] LIVACHE T ET AL: "Preparation of a DNA matrix via an electrochemically directed copolymerization of yrrole and oligonucleotides bearing a pyrrole group", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 22, no. 15, 11 August 1994 (1994-08-11), pages 2915 - 2921, XP002114812, ISSN: 0305-1048
  • [X] PATENT ABSTRACTS OF JAPAN vol. 018, no. 410 (C - 1232) 2 August 1994 (1994-08-02)
  • [A] SPROAT B S ET AL: "NEW SYNTHETIC ROUTES TO PROTECTED PURINE 2'-OMICRON-METHYLRIBOSIDE-3' -OMICRON-PHOSPHORAMIDITES USING A NOVELALKYLATION PROCEDURE", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 18, no. 1, 11 January 1990 (1990-01-11), pages 41 - 49, XP002060669, ISSN: 0305-1048
  • See references of WO 0034343A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0034343 A1 20000615; AU 1750400 A 20000626; CA 2353596 A1 20000615; EP 1155056 A1 20011121; EP 1155056 A4 20040512

DOCDB simple family (application)

US 9928666 W 19991203; AU 1750400 A 19991203; CA 2353596 A 19991203; EP 99960649 A 19991203