EP 1155115 A4 20020327 - METHOD OF MODIFYING CYTOTOXIC CELLS AND USES THEREOF
Title (en)
METHOD OF MODIFYING CYTOTOXIC CELLS AND USES THEREOF
Title (de)
METHODE ZUR MODIFIZIERUNG ZYTOTOXISCHER ZELLEN UND DEREN VERWENDUNGEN
Title (fr)
PROCEDE DE MODIFICATION POUR CELLULES CYTOTOXIQUES ET UTILISATIONS CORRESPONDANTES
Publication
Application
Priority
- US 0004548 W 20000223
- US 12148299 P 19990224
Abstract (en)
[origin: WO0050569A1] TALL-104 cells, and other cytotoxic T cell lines, may be modified to increase the cytotoxicity thereof, to enhance growth properties, and/or to provide a preferred phenotype, e.g., expression of cell surface antigens, function, e.g., change in cytokine production profile, by culturing the cells in an effective amount of IL-15, optionally followed by gamma irradiation to halt proliferation.
IPC 1-7
IPC 8 full level
C12N 5/0783 (2010.01); C12N 5/09 (2010.01); A61K 35/12 (2015.01)
CPC (source: EP)
C12N 5/0636 (2013.01); C12N 5/0694 (2013.01); A61K 2035/124 (2013.01); C12N 2501/23 (2013.01)
Citation (search report)
- [XY] WO 9527722 A1 19951019 - IMMUNEX CORP [US]
- [Y] KANEGANE H ET AL: "ACTIVATION OF NAIVE AND MEMORY T CELLS BY INTERLEUKIN-15", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 88, no. 1, 1 July 1996 (1996-07-01), pages 230 - 235, XP002036242, ISSN: 0006-4971
- [Y] CAESON W E ET AL: "INTERLEUKIN (IL) 15 IS A NOVEL CYTOKINE THAT ACTIVATES HUMAN NATURAL KILLER CELLS VIA COMPONENTS OF THE IL-2 RECEPTOR", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 180, no. 4, 1994, pages 1395 - 1403, XP000670920, ISSN: 0022-1007
- See also references of WO 0050569A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0050569 A1 20000831; AU 3373300 A 20000914; EP 1155115 A1 20011121; EP 1155115 A4 20020327
DOCDB simple family (application)
US 0004548 W 20000223; AU 3373300 A 20000223; EP 00911919 A 20000223