EP 1155361 A2 20011121 - METHODS TO REDUCE VARIANCE IN TREATMENT STUDIES USING GENOTYPING
Title (en)
METHODS TO REDUCE VARIANCE IN TREATMENT STUDIES USING GENOTYPING
Title (de)
VERFAHREN UM VERÄNDERUNGEN IN BEHANDLUNGSSTUDIEN DIE GENOTYPISIERUNG VERWENDEN, ZU VERRINGERN
Title (fr)
PROCEDES VISANT A REDUIRE LA VARIANCE DES ETUDES DE TRAITEMENTS AU MOYEN DE GENOTYPAGE
Publication
Application
Priority
- US 9928582 W 19991201
- US 11066898 P 19981202
Abstract (en)
[origin: WO0033161A2] The present invention provides methods, computer programs and computerized systems useful for evaluating the efficacy of various types of treatment procedures (e.g., clinical trials) as a function of the genotype of a subject. By matching treatment and control groups genetically, the methods and systems of the invention reduce the total variance of the study, thereby allowing trials examining the efficacy or effect of treatment procedures to be conducted with fewer subjects, with increased confidence values, and/or with increased precision or discriminatory power. Certain methods of the invention involve selecting treated and control subpopulations of subjects from treated and control populations for similarity in polymorphic profile, wherein the treated and control populations have been treated with a treatment and control procedure, respectively. A determination is then made whether there is a statistically significant difference in a test parameter between the treated and control subpopulations as an assessment of the test procedure.
IPC 1-7
IPC 8 full level
A01N 43/04 (2006.01); A61K 31/38 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01); G01N 31/00 (2006.01); G01N 33/53 (2006.01); G01N 33/557 (2006.01); G01N 33/564 (2006.01); G06F 1/00 (2006.01)
IPC 8 main group level
G06F (2006.01)
CPC (source: EP)
A61K 45/06 (2013.01); C12Q 1/6883 (2013.01); C12Q 2600/156 (2013.01)
Citation (search report)
See references of WO 0033161A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0033161 A2 20000608; WO 0033161 A3 20001102; WO 0033161 A9 20010419; AU 3108200 A 20000619; CA 2350069 A1 20000608; EP 1155361 A2 20011121; JP 2003501005 A 20030114; MX PA01005513 A 20030714
DOCDB simple family (application)
US 9928582 W 19991201; AU 3108200 A 19991201; CA 2350069 A 19991201; EP 99965095 A 19991201; JP 2000585735 A 19991201; MX PA01005513 A 19991201