EP 1157003 A1 20011128 - ACYLATED AMINOACETONITRILES AS CYSTEINE PROTEASE INHIBITORS
Title (en)
ACYLATED AMINOACETONITRILES AS CYSTEINE PROTEASE INHIBITORS
Title (de)
ACYLIERTE AMINOACETONITRILE ALS CYSTEINPROTEASEINHIBITOR
Title (fr)
INHIBITEURS DE PROTEASE A CYSTEINE A BASE D'AMINOACETONITRILES ACYLES INHIBITEURS DE PROTEASE A CYSTEINE A BASE D'AMINOACETONITRILES ACYLES
Publication
Application
Priority
- GB 0000539 W 20000216
- GB 9903861 A 19990220
Abstract (en)
[origin: WO0048992A1] A compound of formula (I): wherein R<1>, R<2>, R<3> and Ar are defined; a composition comprising a compound of formula (I) and a carrier or diluent; a compound of formula (I) for use as a medicament; the use of a compound of formula (I) in the manufacture of a medicament for use in the inhibition of a cysteine protease in a warm blooded animal; the use of a compound of formula (I) in the manufacture of a medicament for use in the treatment of chronic obstructive pulmonary disease in a warm blooded animal; and a method of treating a Cathepsin L or Cathepsin S mediated disease state in mammals which comprises administering to a mammal in need of such treatment an effective amount of a compound of formula (I).
IPC 1-7
C07C 255/29; C07C 255/25; C07D 307/54; C07D 231/12; C07D 295/08; C07C 323/60; A61K 31/275; A61K 31/33; A61P 19/00; C07D 333/24; C07D 249/18
IPC 8 full level
C07D 249/18 (2006.01); A61K 31/275 (2006.01); A61K 31/33 (2006.01); A61K 31/341 (2006.01); A61K 31/381 (2006.01); A61K 31/4192 (2006.01); A61K 31/4402 (2006.01); A61K 31/5375 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 19/00 (2006.01); A61P 19/08 (2006.01); A61P 21/00 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07C 255/25 (2006.01); C07C 255/29 (2006.01); C07C 321/14 (2006.01); C07C 323/60 (2006.01); C07D 213/30 (2006.01); C07D 231/12 (2006.01); C07D 295/08 (2006.01); C07D 307/54 (2006.01); C07D 333/24 (2006.01)
CPC (source: EP)
A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 19/00 (2017.12); A61P 19/08 (2017.12); A61P 21/00 (2017.12); A61P 29/00 (2017.12); A61P 43/00 (2017.12); C07C 255/29 (2013.01); C07C 323/60 (2013.01); C07D 231/12 (2013.01); C07D 249/18 (2013.01); C07D 295/08 (2013.01); C07D 307/54 (2013.01); C07D 333/24 (2013.01)
Citation (search report)
See references of WO 0048992A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0048992 A1 20000824; AU 2560700 A 20000904; EP 1157003 A1 20011128; GB 9903861 D0 19990414; JP 2002537285 A 20021105
DOCDB simple family (application)
GB 0000539 W 20000216; AU 2560700 A 20000216; EP 00903853 A 20000216; GB 9903861 A 19990220; JP 2000599733 A 20000216