EP 1157009 A1 20011128 - DOPAMINE D1 RECEPTOR AGONIST COMPOUNDS
Title (en)
DOPAMINE D1 RECEPTOR AGONIST COMPOUNDS
Title (de)
ALS DOPAMIN-D1-RECEPTOR-AGONISTEN WIRKENDE VERBINDUNGEN
Title (fr)
COMPOSES AGONISTES DU RECEPTEUR D1 DE DOPAMINE
Publication
Application
Priority
- GB 0000570 W 20000217
- GB 9903671 A 19990217
Abstract (en)
[origin: WO0049000A1] The invention provides 2,3,4,5-tetrahydro-1H-3-benzazepines of general formula (I) wherein: R<1> is hydrogen, halogen, C1-C4 alkyl, or CF3; R<2> is hydrogen, methyl, or lower alkenyl of 3-5 carbon atoms; R<3> and R<4> together form a furan, dihydrofuran, thiophene, dihydrothiophene, cyclopentane or cyclohexane ring and R<5> is hydrogen or R<4> and R<5> together form a furan, dihydrofuran, thiophene, dihydrothiophene, cyclopentane or cyclohexane ring and R<3> is hydrogen; R<6> is hydrogen, halogen, CF3, CN, NO2 or NH2; R<7> is hydrogen, halogen, CF3, CN, NO2 or NH2. The specific combination of substituents: R1 = H, R2 = H and R4 and R5 together forming a cyclohexane ring is excluded, namely 1-(5,6,7,8-tetrahydronaphthalen-2-yl)-2,3,4,5-tetrahydro-1H-benzol[d]azepine-7,8-diol. The compounds of the invention provide therapeutic agents that selectively interact positively with postsynaptic dopamine D1 receptors in the striatum, directly or in-directly (termed dopamine D1 agonists) and are particularly valuable as anti-Parkinsonian agents.
IPC 1-7
C07D 223/16; C07D 405/04; C07D 409/04; A61K 31/55; A61P 25/16
IPC 8 full level
A61K 31/55 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); C07D 223/16 (2006.01); C07D 405/04 (2006.01); C07D 409/04 (2006.01)
CPC (source: EP KR)
A61P 25/16 (2018.01 - EP); A61P 25/28 (2018.01 - EP); C07D 223/16 (2013.01 - EP KR); C07D 405/04 (2013.01 - EP KR); C07D 409/04 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0049000 A1 20000824; AU 2563200 A 20000904; AU 767332 B2 20031106; BR 0008329 A 20020129; CA 2363695 A1 20000824; CN 1142916 C 20040324; CN 1341102 A 20020320; CZ 20012973 A3 20020116; EA 004745 B1 20040826; EA 200100783 A1 20020228; EP 1157009 A1 20011128; GB 9903671 D0 19990414; HU P0200057 A2 20020828; HU P0200057 A3 20040329; IL 144810 A0 20020630; JP 2002537288 A 20021105; KR 20010108228 A 20011207; MX PA01008294 A 20020702; NO 20013978 D0 20010815; NO 20013978 L 20010815; PL 349838 A1 20020923; ZA 200106478 B 20020207
DOCDB simple family (application)
GB 0000570 W 20000217; AU 2563200 A 20000217; BR 0008329 A 20000217; CA 2363695 A 20000217; CN 00803947 A 20000217; CZ 20012973 A 20000217; EA 200100783 A 20000217; EP 00903881 A 20000217; GB 9903671 A 19990217; HU P0200057 A 20000217; IL 14481000 A 20000217; JP 2000599740 A 20000217; KR 20017010418 A 20010816; MX PA01008294 A 20000217; NO 20013978 A 20010815; PL 34983800 A 20000217; ZA 200106478 A 20010807