EP 1157042 B1 20080806 - PRODUCTION OF TETRAVALENT ANTIBODIES
Title (en)
PRODUCTION OF TETRAVALENT ANTIBODIES
Title (de)
HERSTELLUNG TETRAVALENTER ANTIKÖRPER
Title (fr)
PRODUCTION D'ANTICORPS TETRAVALENTS
Publication
Application
Priority
- US 0001893 W 20000128
- US 23874199 A 19990128
Abstract (en)
[origin: EP1970385A2] The present invention relates to biologically active antibody dimers. The dimers can be composed of two antibody molecules having the same antigen binding specificity (homodimer). Alternatively, the dimers can be composed of two different antibody molecules having binding specificity for two distinct antigens (heterodimer). These dimers are useful for inducing hyper-cross-linking of membrane antigens. The present invention further relates to the use of biologically active antibody dimers for the preferential killing or inhibition of selected cell populations in the treatment of diseases such as cancer and autoimmune disorders.
IPC 8 full level
C07K 16/00 (2006.01); C12N 15/09 (2006.01); A61K 39/395 (2006.01); A61K 47/48 (2006.01); A61P 1/00 (2006.01); A61P 11/00 (2006.01); A61P 11/02 (2006.01); A61P 11/06 (2006.01); A61P 17/00 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 37/00 (2006.01); A61P 37/02 (2006.01); A61P 37/08 (2006.01); C07K 16/28 (2006.01); C07K 16/46 (2006.01); C12P 21/08 (2006.01)
CPC (source: EP US)
A61K 47/6835 (2017.08 - EP US); A61P 1/00 (2018.01 - EP); A61P 11/00 (2018.01 - EP); A61P 11/02 (2018.01 - EP); A61P 11/06 (2018.01 - EP); A61P 17/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 35/02 (2018.01 - EP); A61P 37/00 (2018.01 - EP); A61P 37/02 (2018.01 - EP); A61P 37/08 (2018.01 - EP); C07K 16/2851 (2013.01 - EP US); C07K 16/2887 (2013.01 - EP US); C07K 16/468 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); C07K 2317/31 (2013.01 - EP US); C07K 2317/734 (2013.01 - EP US)
Citation (examination)
- WO 9966951 A2 19991229 - IMMUNOMEDICS INC [US], et al
- GHETIE M.A. ET AL, PNAS, vol. 94, July 1997 (1997-07-01), pages 7509 - 7514
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0044788 A1 20000803; AT E403680 T1 20080815; AU 3473100 A 20000818; AU 775577 B2 20040805; CA 2359994 A1 20000803; CY 1108489 T1 20140409; DE 60039752 D1 20080918; DK 1157042 T3 20081208; EP 1157042 A1 20011128; EP 1157042 B1 20080806; EP 1970385 A2 20080917; ES 2311452 T3 20090216; JP 2002536969 A 20021105; PT 1157042 E 20081118; US 2005158828 A1 20050721; US 6897044 B1 20050524
DOCDB simple family (application)
US 0001893 W 20000128; AT 00913253 T 20000128; AU 3473100 A 20000128; CA 2359994 A 20000128; CY 081101269 T 20081106; DE 60039752 T 20000128; DK 00913253 T 20000128; EP 00913253 A 20000128; EP 08104512 A 20000128; ES 00913253 T 20000128; JP 2000596044 A 20000128; PT 00913253 T 20000128; US 1918004 A 20041223; US 23874199 A 19990128