EP 1157123 A1 20011128 - STABLE RECOMBINANT INFLUENZA VIRUSES FREE OF HELPER VIRUSES
Title (en)
STABLE RECOMBINANT INFLUENZA VIRUSES FREE OF HELPER VIRUSES
Title (de)
STABILE REKOMBINANTE INFLUENZAVIREN, DIE FREI VON HELFERVIRUS SIND
Title (fr)
VIRUS DE RECOMBINAISON STABLE DE LA GRIPPE EXEMPT DE VIRUS ASSISTANT
Publication
Application
Priority
- EP 00912548 A 20000303
- EP 0001903 W 20000303
- EP 99104519 A 19990306
Abstract (en)
[origin: EP1035209A1] The invention relates to a recombinant influenza virus for high-yield expression of incorporated foreign gene(s), which is genetically stable in the absence of any helper virus; wherein (a) at least one of the regular viral RNA segments has been exchanged for a vRNA encoding a foreign gene; and/or (b) at least one of the regular viral RNA segments is an ambisense RNA molecule, containing one of the standard viral genes in sense orientation and a foreign, recombinant gene in antisense orientation, or vice versa, in overall convergent arrangement. The present invention further provides a method for the production of said recombinant influenza virus, a method for constructing specific ribozyme-sensitive influenza carrier strains; pharmaceutical compositions comprising said recombinant influenza virus; and the use of said recombinant influenza virus for preparing medicaments for vaccination purposes.
IPC 1-7
C12N 15/86; C12N 7/01; C12N 5/10; A61K 39/00; A61K 39/145; A61K 48/00
IPC 8 full level
A61K 39/00 (2006.01); A61K 39/145 (2006.01); A61K 48/00 (2006.01); A61P 31/00 (2006.01); A61P 31/04 (2006.01); A61P 37/04 (2006.01); C12N 5/10 (2006.01); C12N 7/01 (2006.01); C12N 15/86 (2006.01)
CPC (source: EP)
A61P 31/00 (2017.12); A61P 31/04 (2017.12); A61P 31/16 (2017.12); A61P 37/04 (2017.12); C12N 15/86 (2013.01); C12N 2760/16122 (2013.01); C12N 2760/16143 (2013.01); C12N 2770/24222 (2013.01); C12N 2830/00 (2013.01); C12N 2830/36 (2013.01); C12N 2830/52 (2013.01); C12N 2830/85 (2013.01); C12N 2840/20 (2013.01)
Citation (search report)
See references of WO 0053786A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
EP 1035209 A1 20000913; AU 3427100 A 20000928; CA 2365813 A1 20000914; EP 1157123 A1 20011128; JP 2002537844 A 20021112; NZ 514132 A 20030829; WO 0053786 A1 20000914; ZA 200107284 B 20030226
DOCDB simple family (application)
EP 99104519 A 19990306; AU 3427100 A 20000303; CA 2365813 A 20000303; EP 0001903 W 20000303; EP 00912548 A 20000303; JP 2000603407 A 20000303; NZ 51413200 A 20000303; ZA 200107284 A 20010903