Global Patent Index - EP 1158972 A1

EP 1158972 A1 2001-12-05 - TREATMENT OF HYPERTENSION WITH COMPOUNDS THAT INHIBIT THE DESTRUCTION OF ENKEPHALINS OR ENDORPHINS

Title (en)

TREATMENT OF HYPERTENSION WITH COMPOUNDS THAT INHIBIT THE DESTRUCTION OF ENKEPHALINS OR ENDORPHINS

Title (de)

BEHANDLUNG DES BLUTHOCHDRUCKS MIT VERBINDUNGEN DIE DIE ZERSTÖRUNG DER ENKEPHALINE UND DER ENDORPHINE HEMMEN

Title (fr)

TRAITEMENT DE L'HYPERTENSION AVEC DES COMPOSES INHIBANT LA DESTRUCTION DES ENKEPHALINES OU DES ENDORPHINES

Publication

EP 1158972 A1 (EN)

Application

EP 00903252 A

Priority

  • US 0000722 W
  • US 11572499 P

Abstract (en)

[origin: WO0041686A1] A new class of anti-hypertensive agent is provided by substances that inhibit the breakdown of the endogenous substances, the enkephalins and/or the endorphins. The anti-hypertensive effect of an enkephalin breakdown inhibitor is greatly enhanced by being combined with a beta adrenergic blocking agent, herein designated as beta blocker. Specifically, D-phenylalanine, en enkephalin breakdown inhibitor when used alone produces excellent blood pressure lowering in animals and man. Use of a combination of D-phenylalanine and the beta blocker propranolol provides a greatly enhanced anti-hypertensive effect in the spontaneously hypertensive rat (SHR). Blood pressure lowering by D-phenylalanine, or the latter combination, is very long lasting in the SHR and man. If the blood pressure of the rat or human is normal, D-phenylalanine has little or no effect on blood pressure. The hypotensive effect of D-phenylalanine is prevented by pretreating the SHR with naloxone or naltrexone which are specific antagonists of enkephalins or endorphins.

IPC 1-7 (main, further and additional classification)

A61K 31/195; A61K 31/135; A61K 31/40; A61K 31/70

IPC 8 full level (invention and additional information)

A61K 31/00 (2006.01); A61K 31/195 (2006.01); A61K 31/198 (2006.01); A61K 31/40 (2006.01); A61K 31/401 (2006.01); A61K 31/70 (2006.01); A61K 33/24 (2006.01); A61K 45/06 (2006.01)

CPC (invention and additional information)

A61K 31/7076 (2013.01); A61K 31/00 (2013.01); A61K 31/195 (2013.01); A61K 31/198 (2013.01); A61K 31/40 (2013.01); A61K 31/401 (2013.01); A61K 31/70 (2013.01); A61K 33/24 (2013.01); A61K 45/06 (2013.01)

Combination set (CPC)

  1. A61K 31/195 + A61K 31/135
  2. A61K 31/195 + A61K 31/195
  3. A61K 31/195 + A61K 31/195
  4. A61K 31/195 + A61K 31/195
  5. A61K 31/40 + A61K 31/195
  6. A61K 31/70 + A61K 31/195
  7. A61K 33/24 + A61K 33/06 + A61K 31/70 + A61K 31/195 + A61K 31/195
  8. A61K 31/195 + A61K 2300/00
  9. A61K 31/40 + A61K 2300/00
  10. A61K 31/70 + A61K 2300/00
  11. A61K 33/24 + A61K 2300/00

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0041686 A1 20000720; AU 2502700 A 20000801; CA 2363847 A1 20000720; EP 1158972 A1 20011205; EP 1158972 A4 20030502

INPADOC legal status


2004-07-14 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20040113

2003-08-13 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030701

2003-05-02 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20030317

2003-01-08 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7A 61K 45/00 A, 7A 61K 31/198 B, 7A 61K 31/401 B, 7A 61K 31/52 B, 7A 61P 9/12 B

2001-12-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010813

2001-12-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-12-05 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI