EP 1158972 A4 20030502 - TREATMENT OF HYPERTENSION WITH COMPOUNDS THAT INHIBIT THE DESTRUCTION OF ENKEPHALINS OR ENDORPHINS
Title (en)
TREATMENT OF HYPERTENSION WITH COMPOUNDS THAT INHIBIT THE DESTRUCTION OF ENKEPHALINS OR ENDORPHINS
Title (de)
Behandlung des Bluthochdrucks mit Verbindungen die die Zerstörung der Enkephaline und der Endorphine hemmen
Title (fr)
TRAITEMENT DE L'HYPERTENSION AVEC DES COMPOSES INHIBANT LA DESTRUCTION DES ENKEPHALINES OU DES ENDORPHINES
Publication
Application
Priority
- US 0000722 W 20000112
- US 11572499 P 19990112
Abstract (en)
[origin: WO0041686A1] A new class of anti-hypertensive agent is provided by substances that inhibit the breakdown of the endogenous substances, the enkephalins and/or the endorphins. The anti-hypertensive effect of an enkephalin breakdown inhibitor is greatly enhanced by being combined with a beta adrenergic blocking agent, herein designated as beta blocker. Specifically, D-phenylalanine, en enkephalin breakdown inhibitor when used alone produces excellent blood pressure lowering in animals and man. Use of a combination of D-phenylalanine and the beta blocker propranolol provides a greatly enhanced anti-hypertensive effect in the spontaneously hypertensive rat (SHR). Blood pressure lowering by D-phenylalanine, or the latter combination, is very long lasting in the SHR and man. If the blood pressure of the rat or human is normal, D-phenylalanine has little or no effect on blood pressure. The hypotensive effect of D-phenylalanine is prevented by pretreating the SHR with naloxone or naltrexone which are specific antagonists of enkephalins or endorphins.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/195 (2006.01); A61K 31/198 (2006.01); A61K 31/40 (2006.01); A61K 31/401 (2006.01); A61K 31/70 (2006.01); A61K 33/24 (2019.01); A61K 45/06 (2006.01)
CPC (source: EP US)
A61K 31/00 (2013.01 - EP); A61K 31/195 (2013.01 - EP); A61K 31/198 (2013.01 - EP); A61K 31/40 (2013.01 - EP); A61K 31/401 (2013.01 - EP); A61K 31/70 (2013.01 - EP); A61K 31/7076 (2013.01 - EP); A61K 33/24 (2013.01 - EP US); A61K 45/06 (2013.01 - EP); A61P 9/12 (2017.12 - EP)
Citation (search report)
- [X] US 4749688 A 19880607 - HASLANGER MARTIN F [US], et al
- [X] DD 229931 A1 19851120 - ADW DDR [DD]
- [X] GB 2286528 A 19950823 - WOODWARD ROBERT JOHN [GB]
- See references of WO 0041686A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0041686 A1 20000720; AU 2502700 A 20000801; CA 2363847 A1 20000720; EP 1158972 A1 20011205; EP 1158972 A4 20030502
DOCDB simple family (application)
US 0000722 W 20000112; AU 2502700 A 20000112; CA 2363847 A 20000112; EP 00903252 A 20000112