EP 1158984 A1 20011205 - INHIBITORS OF PRENYL-PROTEIN TRANSFERASE
Title (en)
INHIBITORS OF PRENYL-PROTEIN TRANSFERASE
Title (de)
INHIBITOREN DER PRENYLPROTEIN-TRANSFERASE
Title (fr)
INHIBITEURS DE PRENYL-PROTEINE TRANSFERASE
Publication
Application
Priority
- GB 9900148 A 19990105
- US 9924948 W 19991026
- US 10617798 P 19981029
Abstract (en)
[origin: WO0025788A1] The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit a prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
IPC 1-7
A61K 31/495; C07D 267/00; C07D 281/00; C07D 291/00; C07D 245/00; C07D 487/22; C07D 225/00; C07D 513/22
IPC 8 full level
A61K 31/4985 (2006.01); A61P 1/16 (2006.01); A61P 9/10 (2006.01); A61P 13/12 (2006.01); A61P 25/00 (2006.01); A61P 27/02 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 498/14 (2006.01); C07D 498/18 (2006.01); C07D 498/22 (2006.01)
CPC (source: EP)
A61P 1/16 (2017.12); A61P 9/10 (2017.12); A61P 13/12 (2017.12); A61P 25/00 (2017.12); A61P 27/02 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 498/14 (2013.01); C07D 498/22 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0025788 A1 20000511; AU 1228800 A 20000522; AU 762440 B2 20030626; CA 2348703 A1 20000511; EP 1158984 A1 20011205; EP 1158984 A4 20030521; JP 2002528504 A 20020903
DOCDB simple family (application)
US 9924948 W 19991026; AU 1228800 A 19991026; CA 2348703 A 19991026; EP 99971320 A 19991026; JP 2000579229 A 19991026