Global Patent Index - EP 1158984 A1

EP 1158984 A1 2001-12-05 - INHIBITORS OF PRENYL-PROTEIN TRANSFERASE

Title (en)

INHIBITORS OF PRENYL-PROTEIN TRANSFERASE

Title (de)

INHIBITOREN DER PRENYLPROTEIN-TRANSFERASE

Title (fr)

INHIBITEURS DE PRENYL-PROTEINE TRANSFERASE

Publication

EP 1158984 A1 (EN)

Application

EP 99971320 A

Priority

  • GB 9900148 A
  • US 9924948 W
  • US 10617798 P

Abstract (en)

[origin: WO0025788A1] The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit a prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

IPC 1-7 (main, further and additional classification)

A61K 31/495; C07D 225/00; C07D 245/00; C07D 267/00; C07D 281/00; C07D 291/00; C07D 487/22; C07D 513/22

IPC 8 full level (invention and additional information)

C07D 498/18 (2006.01); A61K 31/4985 (2006.01); A61P 1/16 (2006.01); A61P 9/10 (2006.01); A61P 13/12 (2006.01); A61P 25/00 (2006.01); A61P 27/02 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 498/14 (2006.01); C07D 498/22 (2006.01)

CPC (invention and additional information)

C07D 498/14 (2013.01); C07D 498/22 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0025788 A1 20000511; AU 1228800 A 20000522; AU 762440 B2 20030626; CA 2348703 A1 20000511; EP 1158984 A1 20011205; EP 1158984 A4 20030521; JP 2002528504 A 20020903

INPADOC legal status


2004-01-14 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030621

2003-05-21 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20030403

2003-05-21 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7C 07D 295/073 A

2003-05-21 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7C 07C 255/50 B

2003-05-21 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 61K 31/277 B

2003-05-21 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 61K 31/496 B

2001-12-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010529

2001-12-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-12-05 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20010529;LT PAYMENT 20010529;LV PAYMENT 20010529;MK PAYMENT 20010529;RO PAYMENT 20010529;SI PAYMENT 20010529