Global Patent Index - EP 1158984 A4

EP 1158984 A4 20030521 - INHIBITORS OF PRENYL-PROTEIN TRANSFERASE

Title (en)

INHIBITORS OF PRENYL-PROTEIN TRANSFERASE

Title (de)

Inhibitoren der Prenylprotein-Transferase

Title (fr)

INHIBITEURS DE PRENYL-PROTEINE TRANSFERASE

Publication

EP 1158984 A4 20030521 (EN)

Application

EP 99971320 A 19991026

Priority

  • GB 9900148 A 19990105
  • US 9924948 W 19991026
  • US 10617798 P 19981029

Abstract (en)

[origin: WO0025788A1] The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit a prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

IPC 1-7

C07D 295/073; C07C 255/50; A61K 31/277; A61K 31/496

IPC 8 full level

C07D 498/18 (2006.01); A61K 31/4985 (2006.01); A61P 1/16 (2006.01); A61P 9/10 (2006.01); A61P 13/12 (2006.01); A61P 25/00 (2006.01); A61P 27/02 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 498/14 (2006.01); C07D 498/22 (2006.01)

CPC (source: EP)

A61P 1/16 (2017.12); A61P 9/10 (2017.12); A61P 13/12 (2017.12); A61P 25/00 (2017.12); A61P 27/02 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 498/14 (2013.01); C07D 498/22 (2013.01)

Citation (search report)

  • [E] WO 0001701 A1 20000113 - MERCK & CO INC [US], et al
  • [PA] WO 9909985 A1 19990304 - MERCK & CO INC [US], et al
  • [A] GELB M H ET AL: "PROTEIN PRENYLATION: FROM DISCOVERY TO PROSPECTS FOR CANCER TREATMENT", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, 1998, pages 40 - 48, XP002929841, ISSN: 1367-5931
  • See references of WO 0025788A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0025788 A1 20000511; AU 1228800 A 20000522; AU 762440 B2 20030626; CA 2348703 A1 20000511; EP 1158984 A1 20011205; EP 1158984 A4 20030521; JP 2002528504 A 20020903

DOCDB simple family (application)

US 9924948 W 19991026; AU 1228800 A 19991026; CA 2348703 A 19991026; EP 99971320 A 19991026; JP 2000579229 A 19991026