EP 1158984 A4 20030521 - INHIBITORS OF PRENYL-PROTEIN TRANSFERASE
Title (en)
INHIBITORS OF PRENYL-PROTEIN TRANSFERASE
Title (de)
Inhibitoren der Prenylprotein-Transferase
Title (fr)
INHIBITEURS DE PRENYL-PROTEINE TRANSFERASE
Publication
Application
Priority
- GB 9900148 A 19990105
- US 9924948 W 19991026
- US 10617798 P 19981029
Abstract (en)
[origin: WO0025788A1] The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit a prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
IPC 1-7
IPC 8 full level
C07D 498/18 (2006.01); A61K 31/4985 (2006.01); A61P 1/16 (2006.01); A61P 9/10 (2006.01); A61P 13/12 (2006.01); A61P 25/00 (2006.01); A61P 27/02 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 498/14 (2006.01); C07D 498/22 (2006.01)
CPC (source: EP)
A61P 1/16 (2017.12); A61P 9/10 (2017.12); A61P 13/12 (2017.12); A61P 25/00 (2017.12); A61P 27/02 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 498/14 (2013.01); C07D 498/22 (2013.01)
Citation (search report)
- [E] WO 0001701 A1 20000113 - MERCK & CO INC [US], et al
- [PA] WO 9909985 A1 19990304 - MERCK & CO INC [US], et al
- [A] GELB M H ET AL: "PROTEIN PRENYLATION: FROM DISCOVERY TO PROSPECTS FOR CANCER TREATMENT", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, 1998, pages 40 - 48, XP002929841, ISSN: 1367-5931
- See references of WO 0025788A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0025788 A1 20000511; AU 1228800 A 20000522; AU 762440 B2 20030626; CA 2348703 A1 20000511; EP 1158984 A1 20011205; EP 1158984 A4 20030521; JP 2002528504 A 20020903
DOCDB simple family (application)
US 9924948 W 19991026; AU 1228800 A 19991026; CA 2348703 A 19991026; EP 99971320 A 19991026; JP 2000579229 A 19991026