EP 1159268 A1 20011205 - N-SUBSTITUTED BENzOYL INDOLES AS ESTROGENIC AGENTS
Title (en)
N-SUBSTITUTED BENzOYL INDOLES AS ESTROGENIC AGENTS
Title (de)
N-SUBSTITUIERTE BENZOYLINDOLE ALS ÖSTROGENE MITTEL
Title (fr)
INDOLS BENZOYLES N-SUBSTITUES COMME AGENTS OESTROGENES
Publication
Application
Priority
- US 0004386 W 20000222
- US 26241399 A 19990304
Abstract (en)
[origin: WO0051983A1] The present invention provides compounds of formula (A) wherein R1, R2 and R3 are independently selected from hydrogen, halogen, C1-C6 alkoxy, -CF3, -NO2, cyano, C1-C6 alkyl, trifluoromethyl, -OH or the C1-C12 esters (straight chain or branched) or C1-C12 alkyl ethers thereof, or C1-C6 halogenated ethers, preferably C1-C3 halogenated ethers, including trifluoromthyl ether and trichloromethyl ether; R4 and R5 are independently selected from H or benzyl, the benzyl group being optionally substituted by C1-C6 alkyl, C1-C6 alkoxy, -CF3, or halogen; X is H, C1-C6 alkyl, or CF3; Z is O or S; n is 2 or 3; Y is selected from: a) a moiety of the formula -NR'R' wherein R' is C1-C6 lower alkyl; or b) a moiety selected from the group of (B), (C), (D) or (E); or a pharmaceutically acceptable salt thereof, as well as pharmaceutical formulations and methods of treating or preventing disease states or syndromes which are caused or associated with an estrogen deficiency or an excess of estrogen utilizing these compounds.
IPC 1-7
IPC 8 full level
A61P 19/10 (2006.01); C07D 209/12 (2006.01)
CPC (source: EP)
A61P 5/30 (2017.12); A61P 9/00 (2017.12); A61P 19/10 (2017.12); C07D 209/12 (2013.01)
Citation (search report)
See references of WO 0051983A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0051983 A1 20000908; AR 022797 A1 20020904; AU 3859400 A 20000921; CA 2364914 A1 20000908; CN 1342144 A 20020327; EP 1159268 A1 20011205; JP 2002538141 A 20021112; MX PA01008911 A 20021023
DOCDB simple family (application)
US 0004386 W 20000222; AR P000100898 A 20000301; AU 3859400 A 20000222; CA 2364914 A 20000222; CN 00804545 A 20000222; EP 00917652 A 20000222; JP 2000602211 A 20000222; MX PA01008911 A 20000222