Global Patent Index - EP 1159268 A1

EP 1159268 A1 2001-12-05 - N-SUBSTITUTED BENzOYL INDOLES AS ESTROGENIC AGENTS

Title (en)

N-SUBSTITUTED BENzOYL INDOLES AS ESTROGENIC AGENTS

Title (de)

N-SUBSTITUIERTE BENZOYLINDOLE ALS ÖSTROGENE MITTEL

Title (fr)

INDOLS BENZOYLES N-SUBSTITUES COMME AGENTS OESTROGENES

Publication

EP 1159268 A1 (EN)

Application

EP 00917652 A

Priority

  • US 0004386 W
  • US 26241399 A

Abstract (en)

[origin: WO0051983A1] The present invention provides compounds of formula (A) wherein R1, R2 and R3 are independently selected from hydrogen, halogen, C1-C6 alkoxy, -CF3, -NO2, cyano, C1-C6 alkyl, trifluoromethyl, -OH or the C1-C12 esters (straight chain or branched) or C1-C12 alkyl ethers thereof, or C1-C6 halogenated ethers, preferably C1-C3 halogenated ethers, including trifluoromthyl ether and trichloromethyl ether; R4 and R5 are independently selected from H or benzyl, the benzyl group being optionally substituted by C1-C6 alkyl, C1-C6 alkoxy, -CF3, or halogen; X is H, C1-C6 alkyl, or CF3; Z is O or S; n is 2 or 3; Y is selected from: a) a moiety of the formula -NR'R' wherein R' is C1-C6 lower alkyl; or b) a moiety selected from the group of (B), (C), (D) or (E); or a pharmaceutically acceptable salt thereof, as well as pharmaceutical formulations and methods of treating or preventing disease states or syndromes which are caused or associated with an estrogen deficiency or an excess of estrogen utilizing these compounds.

IPC 1-7 (main, further and additional classification)

C07D 209/12; A61K 31/40; A61P 19/10

IPC 8 full level (invention and additional information)

A61P 19/10 (2006.01); C07D 209/12 (2006.01)

CPC (invention and additional information)

C07D 209/12 (2013.01)

Citation (search report)

See references of WO 0051983A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0051983 A1 20000908; AR 022797 A1 20020904; AU 3859400 A 20000921; CA 2364914 A1 20000908; CN 1342144 A 20020327; EP 1159268 A1 20011205; JP 2002538141 A 20021112; MX PA01008911 A 20021023

INPADOC legal status


2005-09-07 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20050305

2003-11-19 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20031008

2002-06-19 [RAP1] TRANSFER OF RIGHTS OF AN APPLICATION

- Owner name: WYETH

2001-12-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010903

2001-12-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-12-05 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL PAYMENT 20010903;LT PAYMENT 20010903;LV PAYMENT 20010903;MK;RO PAYMENT 20010903;SI PAYMENT 20010903