EP 1159277 A1 20011205 - CRYSTAL MODIFICATION D OF 8-CYANO-1-CYCLOPROPYL-7- (1S, 6S- 2,8- DIAZABICYCLO- 4.3.0 NONAN-8-YL) -6-FLUORO -1,4-DIHYDRO -4-OXO -3-QUINOLINE CARBOXYLIC ACID
Title (en)
CRYSTAL MODIFICATION D OF 8-CYANO-1-CYCLOPROPYL-7- (1S, 6S- 2,8- DIAZABICYCLO- 4.3.0 NONAN-8-YL) -6-FLUORO -1,4-DIHYDRO -4-OXO -3-QUINOLINE CARBOXYLIC ACID
Title (de)
KRISTALLMODIFIKATION D VON 8-CYAN-1-CYCLOPROPYL-7- (1S, 6S- 2,8- DIAZABICYCLO- 4.3.0 NONAN -8-YL) -6-FLUOR -1,4- DIHYDRO -4-OXO -3-C HINOLINCARBONSÄURE
Title (fr)
MODIFICATION CRISTALLINE D DE L'ACIDE 8-CYANO-1- CYCLOPROPYL -7- (1S, 6S- 2,8- DIAZABICYCLO - 4.3.0 NONAN-8-YL) -6-FLUORO -1,4- DIHYDRO -4-OXO -3-QUINOLEINE -CARBOXYLIQUE
Publication
Application
Priority
- DE 19908448 A 19990226
- EP 0001203 W 20000214
Abstract (en)
[origin: US6492391B1] The present invention relates to a defined crystal modification of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, to processes for its preparation and to its use in pharmaceutical preparations.The crystal modification can be distinguished from other crystal modifications of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid of the formula (I) by its characteristic X-ray powder diffractogram and its differential thermodiagram (see description).
IPC 1-7
IPC 8 full level
A61K 31/4709 (2006.01); A61P 31/04 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP KR US)
A61P 31/04 (2017.12 - EP); C07D 471/04 (2013.01 - EP KR US)
Citation (search report)
See references of WO 0052010A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated extension state (EPC)
RO
DOCDB simple family (publication)
US 6492391 B1 20021210; AU 3154400 A 20000921; AU 760710 B2 20030522; BR 0008520 A 20011218; CA 2362804 A1 20000908; CN 1217944 C 20050907; CN 1341116 A 20020320; CZ 20013065 A3 20020116; DE 19908448 A1 20000831; EP 1159277 A1 20011205; HK 1045158 A1 20021115; HK 1045158 B 20060421; HU P0200053 A2 20020529; HU P0200053 A3 20030128; IL 144528 A0 20020523; JP 2002538159 A 20021112; KR 100756474 B1 20070907; KR 20010093300 A 20011027; NO 20014059 D0 20010821; NO 20014059 L 20010821; NO 320314 B1 20051121; NZ 513749 A 20031031; PL 349394 A1 20020715; RU 2248357 C2 20050320; SK 11942001 A3 20011203; TR 200102435 T2 20020121; UA 71606 C2 20041215; WO 0052010 A1 20000908; ZA 200106050 B 20020724
DOCDB simple family (application)
US 91403101 A 20010822; AU 3154400 A 20000214; BR 0008520 A 20000214; CA 2362804 A 20000214; CN 00804306 A 20000214; CZ 20013065 A 20000214; DE 19908448 A 19990226; EP 0001203 W 20000214; EP 00909167 A 20000214; HK 02106690 A 20020912; HU P0200053 A 20000214; IL 14452800 A 20000214; JP 2000602236 A 20000214; KR 20017009632 A 20010731; NO 20014059 A 20010821; NZ 51374900 A 20000214; PL 34939400 A 20000214; RU 2001126301 A 20000214; SK 11942001 A 20000214; TR 200102435 T 20000214; UA 200196577 A 20000214; ZA 200106050 A 20010724