EP 1159294 A1 20011205 - CARBOHYDRATE EPITOPE MIMIC PEPTIDES AND USES THEREOF
Title (en)
CARBOHYDRATE EPITOPE MIMIC PEPTIDES AND USES THEREOF
Title (de)
KOHLENHYDRATEPITOPE-NACHAHMENDE PEPTIDE UND IHRE ANWENDUNGEN
Title (fr)
PEPTIDES MIMETIQUES D'EPITOPE GLUCIDIQUE ET UTILISATIONS CORRESPONDANTES
Publication
Application
Priority
- US 0004730 W 20000224
- US 12132799 P 19990224
- US 25697099 A 19990224
- US 15549299 P 19990923
- US 40443199 A 19990923
- US 51195600 A 20000223
Abstract (en)
[origin: CA2363601A1] This invention provides carbohydrate epitope mimic compounds, particularly peptides, and analogs and variants thereof. In particular, the compounds and peptides of the present invention mimic the carbohydrate epitope GlcA.beta.1→3Gal.beta.1→4GlcNAc or sulfate - 3GlcA.beta.1→3Gal.beta.1→4GlcNAc, or the L2/HNK1 carbohydr ate epitope. This invention provides an isolated peptide comprising an amino aci d sequence of a carbohydrate epitope mimic peptide in which the amino acid sequence is set forth in any of SEQ ID NOS: 1-8, 27-38, 39, 40 and 41, including variants, analogs and active fragments thereof. The invention further provides an isolated nucleic acid encoding a peptide comprising an amino acid sequence of a carbohydrate epitope mimic peptide. This invention provides pharmaceutical compositions and diagnostic and therapeutic methods of use of the isolated polypeptides and nucleic acids, particularly in modulati ng or mediating cell-cell adhesion and viral infection and the processes and events mediated thereby. Assays for compounds which mimic, alter or inactiva te the polypeptides of the present invention for use in therapy are also provid ed.
IPC 1-7
C07K 7/08; C07K 5/10; C12N 15/62; G01N 33/68; C07K 7/06; A61P 25/28
IPC 8 full level
A61P 25/28 (2006.01); C07K 5/10 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C12N 15/62 (2006.01); G01N 33/68 (2006.01)
Citation (search report)
See references of WO 0050447A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
AU 2884100 A 20000914; CA 2363601 A1 20000831; EP 1159294 A1 20011205
DOCDB simple family (application)
AU 2884100 A 20000224; CA 2363601 A 20000224; EP 00907319 A 20000224