Global Patent Index - EP 1159294 A1

EP 1159294 A1 2001-12-05 - CARBOHYDRATE EPITOPE MIMIC PEPTIDES AND USES THEREOF

Title (en)

CARBOHYDRATE EPITOPE MIMIC PEPTIDES AND USES THEREOF

Title (de)

KOHLENHYDRATEPITOPE-NACHAHMENDE PEPTIDE UND IHRE ANWENDUNGEN

Title (fr)

PEPTIDES MIMETIQUES D'EPITOPE GLUCIDIQUE ET UTILISATIONS CORRESPONDANTES

Publication

EP 1159294 A1 (EN)

Application

EP 00907319 A

Priority

  • US 0004730 W
  • US 12132799 P
  • US 25697099 A
  • US 15549299 P
  • US 40443199 A
  • US 51195600 A

Abstract (en)

[origin: CA2363601A1] This invention provides carbohydrate epitope mimic compounds, particularly peptides, and analogs and variants thereof. In particular, the compounds and peptides of the present invention mimic the carbohydrate epitope GlcA.beta.1→3Gal.beta.1→4GlcNAc or sulfate - 3GlcA.beta.1→3Gal.beta.1→4GlcNAc, or the L2/HNK1 carbohydr ate epitope. This invention provides an isolated peptide comprising an amino aci d sequence of a carbohydrate epitope mimic peptide in which the amino acid sequence is set forth in any of SEQ ID NOS: 1-8, 27-38, 39, 40 and 41, including variants, analogs and active fragments thereof. The invention further provides an isolated nucleic acid encoding a peptide comprising an amino acid sequence of a carbohydrate epitope mimic peptide. This invention provides pharmaceutical compositions and diagnostic and therapeutic methods of use of the isolated polypeptides and nucleic acids, particularly in modulati ng or mediating cell-cell adhesion and viral infection and the processes and events mediated thereby. Assays for compounds which mimic, alter or inactiva te the polypeptides of the present invention for use in therapy are also provid ed.

IPC 1-7 (main, further and additional classification)

C07K 7/08; A61P 25/28; C07K 5/10; C07K 7/06; C12N 15/62; G01N 33/68

IPC 8 full level (invention and additional information)

A61P 25/28 (2006.01); C07K 5/10 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C12N 15/62 (2006.01); G01N 33/68 (2006.01)

Citation (search report)

See references of WO 0050447A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

AU 2884100 A 20000914; CA 2363601 A1 20000831; EP 1159294 A1 20011205

INPADOC legal status


2004-09-15 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20040303

2003-12-10 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20031023

2001-12-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010921

2001-12-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-12-05 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI