Global Patent Index - EP 1161244 A2

EP 1161244 A2 2001-12-12 - USE OF 1,2,4-TRIAZOLO¬1,5-A PYRIMIDINE DERIVATIVES FOR TREATING MIGRAINE

Title (en)

USE OF 1,2,4-TRIAZOLO¬1,5-A PYRIMIDINE DERIVATIVES FOR TREATING MIGRAINE

Title (de)

VERWENDUNG VON 1,2,4-TRIAZOLO¬1,5-A PYRIMIDIN DERIVATIVEN ZUR BEHANDLUNG VON MIGRÄNE

Title (fr)

COMPOSES A USAGE THERAPEUTIQUE

Publication

EP 1161244 A2 (EN)

Application

EP 00916901 A

Priority

  • EP 0001930 W
  • GB 9906130 A

Abstract (en)

[origin: WO0056292A2] A method of treating migraine comprising the administration of a therapeutically effective amount of a compound of formula (I) including pharmaceutically acceptable salts, solvates, racemates, enantiomers, diastereoisomers and mixtures thereof in which: R1 represents H or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino): C1-6alkyl, C1-6alkoxy or C1-6alkanoyl; R2 and R3 independently represent H or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino): C1-6alkyl, C1-6alkoxy, C1-6alkanoyl, C1-6alkylthio, C1-6alkylsulphinyl, C1-6alkylsulphonyl or hydroxy; R4 and R5 independently represent H, C1-6alkyl or R4 and R5 combined together with the carbon atom to which they are attached represent C3-6cycloalkylidene (each alkyl or cycloalkylidene being optionally substituted with one or more of halo, cyano, hydroxy, amino or C1-6alkyl); and R6, R7 and R8 independently represent H, halo, hydroxy, mercapto, nitro, cyano or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino; and any nitrogen atom being optionally substituted with one or more C1-6alkyl): C1-6alkyl, C1-6alkanoyl, C1-6alkoxy, C2-6alkoxycarbonyl, carboxy, C1-6alkanoyloxy, C1-6alkylthio, C1-6alkylsulphinyl, C1-6alkylsulphonyl, C1-6alkylsulphonylamino, sulphamoyl, carbamoyl, C2-6alkylcarbamoyl or C1-6alkanoylamino; to a mammal in need thereof.

IPC 1-7 (main, further and additional classification)

A61K 31/519; A61P 25/06

IPC 8 full level (invention and additional information)

C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61P 25/06 (2006.01)

CPC (invention and additional information)

A61K 31/519 (2013.01)

Citation (search report)

See references of WO 0056292A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

Designated extension state (EPC)

LT LV MK RO

EPO simple patent family

WO 0056292 A2 20000928; WO 0056292 A3 20010405; AU 3808800 A 20001009; CA 2365115 A1 20000928; CN 1350457 A 20020522; EP 1161244 A2 20011212; GB 9906130 D0 19990512; JP 2002539241 A 20021119; MX PA01009386 A 20040319

INPADOC legal status


2007-11-07 [RTI1] TITLE (CORRECTION)

- Free text: USE OF 1,2,4-TRIAZOLO??1,5-A PYRIMIDINE DERIVATIVES FOR TREATING MIGRAINE

2004-04-21 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20031101

2001-12-12 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20011010

2001-12-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-12-12 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT PAYMENT 20011010;LV PAYMENT 20011010;MK PAYMENT 20011010;RO PAYMENT 20011010;SI