EP 1161244 A2 20011212 - USE OF 1,2,4-TRIAZOLO¬1,5-A PYRIMIDINE DERIVATIVES FOR TREATING MIGRAINE
Title (en)
USE OF 1,2,4-TRIAZOLO¬1,5-A PYRIMIDINE DERIVATIVES FOR TREATING MIGRAINE
Title (de)
VERWENDUNG VON 1,2,4-TRIAZOLO¬1,5-A PYRIMIDIN DERIVATIVEN ZUR BEHANDLUNG VON MIGRÄNE
Title (fr)
COMPOSES A USAGE THERAPEUTIQUE
Publication
Application
Priority
- EP 0001930 W 20000306
- GB 9906130 A 19990318
Abstract (en)
[origin: WO0056292A2] A method of treating migraine comprising the administration of a therapeutically effective amount of a compound of formula (I) including pharmaceutically acceptable salts, solvates, racemates, enantiomers, diastereoisomers and mixtures thereof in which: R1 represents H or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino): C1-6alkyl, C1-6alkoxy or C1-6alkanoyl; R2 and R3 independently represent H or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino): C1-6alkyl, C1-6alkoxy, C1-6alkanoyl, C1-6alkylthio, C1-6alkylsulphinyl, C1-6alkylsulphonyl or hydroxy; R4 and R5 independently represent H, C1-6alkyl or R4 and R5 combined together with the carbon atom to which they are attached represent C3-6cycloalkylidene (each alkyl or cycloalkylidene being optionally substituted with one or more of halo, cyano, hydroxy, amino or C1-6alkyl); and R6, R7 and R8 independently represent H, halo, hydroxy, mercapto, nitro, cyano or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino; and any nitrogen atom being optionally substituted with one or more C1-6alkyl): C1-6alkyl, C1-6alkanoyl, C1-6alkoxy, C2-6alkoxycarbonyl, carboxy, C1-6alkanoyloxy, C1-6alkylthio, C1-6alkylsulphinyl, C1-6alkylsulphonyl, C1-6alkylsulphonylamino, sulphamoyl, carbamoyl, C2-6alkylcarbamoyl or C1-6alkanoylamino; to a mammal in need thereof.
IPC 1-7
IPC 8 full level
A61K 31/519 (2006.01); A61P 25/06 (2006.01); C07D 487/04 (2006.01)
CPC (source: EP)
A61K 31/519 (2013.01); A61P 25/06 (2017.12)
Citation (search report)
See references of WO 0056292A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated extension state (EPC)
LT LV MK RO
DOCDB simple family (publication)
WO 0056292 A2 20000928; WO 0056292 A3 20010405; AU 3808800 A 20001009; CA 2365115 A1 20000928; CN 1350457 A 20020522; EP 1161244 A2 20011212; GB 9906130 D0 19990512; JP 2002539241 A 20021119; MX PA01009386 A 20040319
DOCDB simple family (application)
EP 0001930 W 20000306; AU 3808800 A 20000306; CA 2365115 A 20000306; CN 00807524 A 20000306; EP 00916901 A 20000306; GB 9906130 A 19990318; JP 2000606198 A 20000306; MX PA01009386 A 20000306