EP 1161258 A1 20011212 - COMPOSITIONS AND METHODS OF USE OF LDL-LIKE RECEPTOR LIGANDS FOR THE TREATMENT OF CANCER AND ANGIOGENIC-BASED DISEASE
Title (en)
COMPOSITIONS AND METHODS OF USE OF LDL-LIKE RECEPTOR LIGANDS FOR THE TREATMENT OF CANCER AND ANGIOGENIC-BASED DISEASE
Title (de)
ZUSAMMENSETZUNGEN UND VERFAHRUNGEN VON LDL REZEPTOR ODER DERGLEICHEN LIGANDEN ZUR BEHANDLUNG VON KREBS UND ANGIOGENISCHEN ERKRANKUNGEN
Title (fr)
COMPOSITIONS ET PROCEDES D'UTILISATION DE LIGANDS RECEPTEURS DU TYPE LDL POUR LE TRAITEMENT DU CANCER ET DE MALADIES ANGIOGENIQUES
Publication
Application
Priority
- US 0007154 W 20000317
- US 27098299 A 19990317
Abstract (en)
[origin: WO0054801A1] Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise naturally occuring or synthetic protein, peptide, or protein fragment capable of binding to low density lipoprotein (or low density lipoprotein-like) receptors. The compositions may be administred using a pharmaceutically acceptable carrier. The methods involve administering to a human or animal the compositions described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes, such as cancer, mediated by undesired and uncontrolled cell proliferation particularly by inhibiting angiogenesis. Administration of the compositions of the present invention to a human or animal having prevascularized metastasized tumors is useful for preventing the growth or expansion of such tumors.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 38/39 (2006.01); A61K 38/43 (2006.01); A61K 38/46 (2006.01); A61K 38/48 (2006.01); A61K 38/55 (2006.01); A61K 38/57 (2006.01); A61P 19/02 (2006.01); A61P 27/02 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP)
A61K 38/1709 (2013.01); A61K 38/57 (2013.01); A61P 19/02 (2017.12); A61P 27/02 (2017.12); A61P 35/00 (2017.12)
Citation (search report)
See references of WO 0054801A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0054801 A1 20000921; AU 4449900 A 20001004; CA 2367247 A1 20000921; EP 1161258 A1 20011212; JP 2002539174 A 20021119
DOCDB simple family (application)
US 0007154 W 20000317; AU 4449900 A 20000317; CA 2367247 A 20000317; EP 00925874 A 20000317; JP 2000604873 A 20000317