Global Patent Index - EP 1161258 A1

EP 1161258 A1 2001-12-12 - COMPOSITIONS AND METHODS OF USE OF LDL-LIKE RECEPTOR LIGANDS FOR THE TREATMENT OF CANCER AND ANGIOGENIC-BASED DISEASE

Title (en)

COMPOSITIONS AND METHODS OF USE OF LDL-LIKE RECEPTOR LIGANDS FOR THE TREATMENT OF CANCER AND ANGIOGENIC-BASED DISEASE

Title (de)

ZUSAMMENSETZUNGEN UND VERFAHRUNGEN VON LDL REZEPTOR ODER DERGLEICHEN LIGANDEN ZUR BEHANDLUNG VON KREBS UND ANGIOGENISCHEN ERKRANKUNGEN

Title (fr)

COMPOSITIONS ET PROCEDES D'UTILISATION DE LIGANDS RECEPTEURS DU TYPE LDL POUR LE TRAITEMENT DU CANCER ET DE MALADIES ANGIOGENIQUES

Publication

EP 1161258 A1 (EN)

Application

EP 00925874 A

Priority

  • US 0007154 W
  • US 27098299 A

Abstract (en)

[origin: WO0054801A1] Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise naturally occuring or synthetic protein, peptide, or protein fragment capable of binding to low density lipoprotein (or low density lipoprotein-like) receptors. The compositions may be administred using a pharmaceutically acceptable carrier. The methods involve administering to a human or animal the compositions described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes, such as cancer, mediated by undesired and uncontrolled cell proliferation particularly by inhibiting angiogenesis. Administration of the compositions of the present invention to a human or animal having prevascularized metastasized tumors is useful for preventing the growth or expansion of such tumors.

IPC 1-7 (main, further and additional classification)

A61K 38/48; A61K 38/17; A61K 38/39; A61K 38/57; A61P 35/00

IPC 8 full level (invention and additional information)

A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 38/39 (2006.01); A61K 38/43 (2006.01); A61K 38/46 (2006.01); A61K 38/48 (2006.01); A61K 38/55 (2006.01); A61K 38/57 (2006.01); A61P 19/02 (2006.01); A61P 27/02 (2006.01); A61P 35/00 (2006.01)

CPC (invention and additional information)

A61K 38/1709 (2013.01); A61K 38/57 (2013.01)

Combination set (CPC)

  1. A61K 38/57 + A61K 2300/00
  2. A61K 38/1709 + A61K 2300/00

Citation (search report)

See references of WO 0054801A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0054801 A1 20000921; AU 4449900 A 20001004; CA 2367247 A1 20000921; EP 1161258 A1 20011212; JP 2002539174 A 20021119

INPADOC legal status


2003-04-16 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20021001

2002-07-24 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20020610

2001-12-12 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20011004

2001-12-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-12-12 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL;LT;LV;MK;RO;SI