Global Patent Index - EP 1161261 A1

EP 1161261 A1 2001-12-12 - APOPTOSIS INDUCING MOLECULE II AND METHODS OF USE

Title (en)

APOPTOSIS INDUCING MOLECULE II AND METHODS OF USE

Title (de)

APOPTOSE-INDUZIERENDES MOLEKÜL II UND VERWENDUNGSVERFAHREN

Title (fr)

MOLECULE II INDUISANT L'APOPTOSE ET TECHNIQUES D'UTILISATION

Publication

EP 1161261 A1 (EN)

Application

EP 00914913 A

Priority

  • US 0006332 W
  • US 12404199 P
  • US 13745799 P
  • US 14265799 P
  • US 14832699 P
  • US 16838099 P

Abstract (en)

[origin: WO0053223A1] The present invention relates to a novel member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM II). AIM II polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, aberrant bone development, autoimmune and other immune system deseases, graft versus host desease, rheumatoid arthritis, osteoarthritis and to inhibit neoplasia, such as tumor cell growth.

IPC 1-7 (main, further and additional classification)

A61K 39/395; A61K 38/17; A61P 35/00; A61P 37/00; C07K 14/705

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 45/06 (2006.01); A61K 47/48 (2006.01); A61P 11/00 (2006.01); A61P 19/00 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61P 37/02 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 14/525 (2006.01); C07K 14/705 (2006.01); C07K 16/24 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); C12P 21/02 (2006.01); C12R 1/91 (2006.01)

CPC (invention and additional information)

C07K 16/2875 (2013.01); A61K 45/06 (2013.01); C07K 14/4747 (2013.01); C07K 14/70575 (2013.01); C07K 16/2866 (2013.01); A61K 38/00 (2013.01); C07K 2317/21 (2013.01); C07K 2317/34 (2013.01); C07K 2317/622 (2013.01); C07K 2319/30 (2013.01)

Citation (search report)

See references of WO 0053223A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0053223 A1 20000914; AU 3623700 A 20000928; CA 2367315 A1 20000914; EP 1161261 A1 20011212; JP 2003528030 A 20030924

INPADOC legal status


2007-05-09 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20061001

2006-02-22 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: HUMAN GENOME SCIENCES, INC.

2001-12-12 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20011011

2001-12-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-12-12 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL;LT;LV;MK;RO;SI