EP 1161261 A1 20011212 - APOPTOSIS INDUCING MOLECULE II AND METHODS OF USE
Title (en)
APOPTOSIS INDUCING MOLECULE II AND METHODS OF USE
Title (de)
APOPTOSE-INDUZIERENDES MOLEKÜL II UND VERWENDUNGSVERFAHREN
Title (fr)
MOLECULE II INDUISANT L'APOPTOSE ET TECHNIQUES D'UTILISATION
Publication
Application
Priority
- US 0006332 W 20000310
- US 12404199 P 19990311
- US 13745799 P 19990604
- US 14265799 P 19990706
- US 14832699 P 19990811
- US 16838099 P 19991202
Abstract (en)
[origin: WO0053223A1] The present invention relates to a novel member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM II). AIM II polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, aberrant bone development, autoimmune and other immune system deseases, graft versus host desease, rheumatoid arthritis, osteoarthritis and to inhibit neoplasia, such as tumor cell growth.
IPC 1-7
A61K 39/395; A61K 38/17; C07K 14/705; A61P 37/00; A61P 35/00
IPC 8 full level
A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 45/06 (2006.01); A61K 47/48 (2006.01); A61P 11/00 (2006.01); A61P 19/00 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61P 37/02 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 14/525 (2006.01); C07K 14/705 (2006.01); C07K 16/24 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61K 45/06 (2013.01); A61P 11/00 (2017.12); A61P 19/00 (2017.12); A61P 29/00 (2017.12); A61P 31/00 (2017.12); A61P 35/00 (2017.12); A61P 37/00 (2017.12); A61P 37/02 (2017.12); A61P 37/08 (2017.12); A61P 43/00 (2017.12); C07K 14/4747 (2013.01); C07K 14/70575 (2013.01); C07K 16/2866 (2013.01); C07K 16/2875 (2013.01); A61K 38/00 (2013.01); C07K 2317/21 (2013.01); C07K 2317/34 (2013.01); C07K 2317/622 (2013.01); C07K 2319/30 (2013.01)
Citation (search report)
See references of WO 0053223A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0053223 A1 20000914; AU 3623700 A 20000928; CA 2367315 A1 20000914; EP 1161261 A1 20011212; JP 2003528030 A 20030924
DOCDB simple family (application)
US 0006332 W 20000310; AU 3623700 A 20000310; CA 2367315 A 20000310; EP 00914913 A 20000310; JP 2000603712 A 20000310